Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4436391..4437016 Replicon chromosome
Accession NZ_CP069994
Organism Klebsiella pneumoniae strain FDAARGOS_1321

Toxin (Protein)


Gene name vapC Uniprot ID R4Y4A3
Locus tag I6K51_RS21500 Protein ID WP_002882817.1
Coordinates 4436633..4437016 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag I6K51_RS21495 Protein ID WP_004150355.1
Coordinates 4436391..4436633 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K51_RS21470 4432382..4432981 + 600 WP_004151865.1 glucose-1-phosphatase -
I6K51_RS21475 4432975..4433835 + 861 WP_004146232.1 virulence factor BrkB family protein -
I6K51_RS21480 4433832..4434269 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
I6K51_RS21485 4434314..4435255 + 942 WP_004178031.1 fatty acid biosynthesis protein FabY -
I6K51_RS21490 4435269..4436186 - 918 WP_009484979.1 alpha/beta hydrolase -
I6K51_RS21495 4436391..4436633 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
I6K51_RS21500 4436633..4437016 + 384 WP_002882817.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K51_RS21505 4437190..4438119 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
I6K51_RS21510 4438116..4438751 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
I6K51_RS21515 4438748..4439650 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14377.62 Da        Isoelectric Point: 7.3178

>T192572 WP_002882817.1 NZ_CP069994:4436633-4437016 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGRREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T192572 NZ_CP092460:737519-737860 [Dickeya fangzhongdai]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGCGAAGCCCTGCCTAGCACCCGTGGCTGTCTGGCAAATGCTACTGAC
CCGCCTGCTGAAACAGCACTATGGTCTCACCCTCAACGACACACCGTTCAGTGAGGAACGTGTTATACAGGAACATATCG
ATGCCGGAATCACGCTGGCTGATGCCGTGAATTTTCTGGTGGAAAAATACGAACTGGTGCGTATCGACAGGAAGGGATTT
AACTGGCAGGAACAATCCCCTTATCTCCGGGCTGTAGACATTCTGCGAGCACGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAAAAATTCGGTACGGTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT192572 WP_004150355.1 NZ_CP069994:4436391-4436633 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT192572 NZ_CP092460:737181-737498 [Dickeya fangzhongdai]
ATGACCCACATCAACTGGGGCCTGCAGCGGGCTATCACGCCGCGCCTGGGAGCCCGTCTGGTGCAGGAGGGTAACCGACT
GCACTATCTGGCTGACAGGGCCAGCATCACCGGCAGGTTCAGTGACACCGAATGCCGGAAGCTGGATGAAACATGCCCGC
ACTTTATCCGCCAGATGGAGTCGATGCTAACCACCGGTGAACTCAGTCCCCAACACGCCCACTGCGTCACCCTGTACCAC
AACGGTTTCACCTGCGAAGCCGATACTCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGAGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GPK8

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References