Detailed information of TA system TA192561

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1698257..1699845
• Replicon: chromosome
• Accession: NZ_CP069994
• Organism: Klebsiella pneumoniae strain FDAARGOS_1321

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486MZ73
• Locus tag: I6K51_RS08190
• Protein ID: WP_009485244.1
• Coordinates: 1698523..1699845 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: I6K51_RS08185
• Protein ID: WP_002904790.1
• Coordinates: 1698257..1698523 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K51_RS08160	1693407..1694330	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
I6K51_RS08165	1694311..1695465	-	1155	WP_009485247.1	FAD-dependent urate hydroxylase HpxO	-
I6K51_RS08170	1695811..1697190	+	1380	WP_004184021.1	purine permease	-
I6K51_RS08175	1697168..1697668	+	501	WP_002904787.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6K51_RS08180	1697665..1697991	+	327	WP_009485245.1	hydroxyisourate hydrolase	-
I6K51_RS08185	1698257..1698523	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K51_RS08190	1698523..1699845	+	1323	WP_009485244.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K51_RS08195	1699862..1701154	-	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
I6K51_RS08200	1701296..1702300	-	1005	WP_009485243.1	type 1 fimbrial protein	-
I6K51_RS08205	1702288..1704789	-	2502	WP_009485242.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49157.50 Da
• Isoelectric Point: 7.5062

>T192561 WP_009485244.1 NZ_CP069994:1698523-1699845 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPICEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T192561 NZ_CP092453:52068-52448 [Escherichia coli]
ATGAGGCATATATCACCGGAAGAACTTATTGCGCTTCATGATGCGAATATAAACCGCTACGGCGGCCTGCCGGGAATGTC
TGATCCGGGTAGGGCAGAGGCCATTATCGGGAGAGTTCAGGCCAGAGTTGCCTACGAAGAGATCACCGACCTTTTCGAAG
TCTCCGCCACCTACCTGGTGGCTACAGCGAGAGGGCATATATTCAATGATGCCAATAAGCGTACCGCGCTAAACAGTGCG
CTGTTATTTCTACGCCGTAACGGGGTGCAGGTATTTGATTCACCTGAACTGGCAGACCTTACCGTAGGGGCTGCGACCGG
AGAGATATCTGTATCTTCTGTCGCCGACACGTTACGTAGATTGTATGGTTCTGCGGAGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT192561 WP_002904790.1 NZ_CP069994:1698257-1698523 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT192561 NZ_CP092453:51847-52068 [Escherichia coli]
ATGCAATCCATTAACTTCCGTACCGCGCGCGGCAACCTTTCTGAAGTGCTCAACAATGTTGAGGCCGGGGAAGAGGTTGA
AATCACCCGCAGAGGCCGTGAGCCAGCAGTAATTGTCAGCAAGGCTACTTTCGAAGCCTACAAAAAAGCGGCGCTGGATG
CTGAATTTGCATCCCTGTTTGACACCCTGGACTCCACCAACAAGGAACTGGTTAACCGATAA

Structures

Toxin

• AlphaFold DB: A0A486MZ73

Antitoxin

• AlphaFold DB: A0A0H3GXD8