Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 388392..389011 Replicon chromosome
Accession NZ_CP069994
Organism Klebsiella pneumoniae strain FDAARGOS_1321

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K51_RS01890 Protein ID WP_002892050.1
Coordinates 388392..388610 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K51_RS01895 Protein ID WP_002892066.1
Coordinates 388637..389011 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K51_RS01855 384440..384703 + 264 WP_002892011.1 type B 50S ribosomal protein L31 -
I6K51_RS01860 384703..384843 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K51_RS01865 384840..385538 - 699 WP_002892021.1 GNAT family N-acetyltransferase -
I6K51_RS01870 385683..387089 + 1407 WP_020316531.1 PLP-dependent aminotransferase family protein -
I6K51_RS01875 387064..387534 - 471 WP_002892026.1 YlaC family protein -
I6K51_RS01880 387555..387695 + 141 WP_004147370.1 hypothetical protein -
I6K51_RS01885 387667..388233 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K51_RS01890 388392..388610 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K51_RS01895 388637..389011 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K51_RS01900 389497..392643 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K51_RS01905 392666..393859 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192560 WP_002892050.1 NZ_CP069994:c388610-388392 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T192560 NZ_CP092452:c4159498-4159325 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT192560 WP_002892066.1 NZ_CP069994:c389011-388637 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT192560 NZ_CP092452:c4159822-4159526 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References