Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4315322..4315947 Replicon chromosome
Accession NZ_CP069992
Organism Klebsiella pneumoniae strain FDAARGOS_1329

Toxin (Protein)


Gene name vapC Uniprot ID A0A378FVD4
Locus tag I6K59_RS21115 Protein ID WP_019705794.1
Coordinates 4315564..4315947 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID J2DFR0
Locus tag I6K59_RS21110 Protein ID WP_004150355.1
Coordinates 4315322..4315564 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K59_RS21085 4311313..4311912 + 600 WP_004151865.1 glucose-1-phosphatase -
I6K59_RS21090 4311906..4312766 + 861 WP_004146232.1 virulence factor BrkB family protein -
I6K59_RS21095 4312763..4313200 + 438 WP_002882809.1 D-tyrosyl-tRNA(Tyr) deacylase -
I6K59_RS21100 4313245..4314186 + 942 WP_012543287.1 fatty acid biosynthesis protein FabY -
I6K59_RS21105 4314200..4315117 - 918 WP_012737090.1 alpha/beta hydrolase -
I6K59_RS21110 4315322..4315564 + 243 WP_004150355.1 ribbon-helix-helix domain-containing protein Antitoxin
I6K59_RS21115 4315564..4315947 + 384 WP_019705794.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K59_RS21120 4316121..4317050 - 930 WP_004150358.1 formate dehydrogenase accessory protein FdhE -
I6K59_RS21125 4317047..4317682 - 636 WP_002882818.1 formate dehydrogenase cytochrome b556 subunit -
I6K59_RS21130 4317679..4318581 - 903 WP_002882822.1 formate dehydrogenase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-112)

Antitoxin

Predicted DNA-binding protein, ribbon-helix-helix domain

(16-47)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14358.57 Da        Isoelectric Point: 6.8806

>T192554 WP_019705794.1 NZ_CP069992:4315564-4315947 [Klebsiella pneumoniae]
MTSGSALFDTNILIDLFSGHREAKQALEAWPPQNAISLITWMEVMVGAKKYHQEQRTRMALSTFNIINISQDIAERSVAL
RQEYKLKLPDAIILATAQLHRLELITRNTKDFAGIPGVVTPYEIHPE

Download         Length: 384 bp

>T192554 NZ_CP092452:2605493-2605600 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGGACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9567.83 Da        Isoelectric Point: 4.3509

>AT192554 WP_004150355.1 NZ_CP069992:4315322-4315564 [Klebsiella pneumoniae]
MMAERDMGRILLDLSDDVIQRLDDLKVQRNIPRAELLREAVEQYLEKQDRAKDTISSALGLWQDCEEDGMEYQRQLRKEW

Download         Length: 243 bp

>AT192554 NZ_CP092452:c2605443-2605380 [Escherichia coli]
TCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378FVD4

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GGU9

References