Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4031468..4032207 Replicon chromosome
Accession NZ_CP069992
Organism Klebsiella pneumoniae strain FDAARGOS_1329

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag I6K59_RS19750 Protein ID WP_032415800.1
Coordinates 4031468..4031953 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag I6K59_RS19755 Protein ID WP_003026799.1
Coordinates 4031941..4032207 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K59_RS19725 4026596..4027951 + 1356 WP_032415797.1 aromatic acid/H+ symport family MFS transporter -
I6K59_RS19730 4028197..4028487 + 291 WP_002921931.1 HTH-type transcriptional regulator -
I6K59_RS19735 4028740..4028952 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
I6K59_RS19740 4029051..4030670 - 1620 WP_032415799.1 ATP-binding cassette domain-containing protein -
I6K59_RS19745 4030972..4031124 - 153 WP_002922102.1 type I toxin-antitoxin system toxin HokA -
I6K59_RS19750 4031468..4031953 - 486 WP_032415800.1 GNAT family N-acetyltransferase Toxin
I6K59_RS19755 4031941..4032207 - 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
I6K59_RS19760 4032340..4032768 - 429 WP_004901287.1 GFA family protein -
I6K59_RS19770 4034635..4036704 - 2070 WP_002922127.1 glycine--tRNA ligase subunit beta -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4032969..4033694 725


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17624.46 Da        Isoelectric Point: 10.1428

>T192553 WP_032415800.1 NZ_CP069992:c4031953-4031468 [Klebsiella pneumoniae]
VGRITAPEPLCSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLRGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKPSQTQPRTLFLRLP
Q

Download         Length: 486 bp

>T192553 NZ_CP092452:2604423-2604530 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT192553 WP_003026799.1 NZ_CP069992:c4032207-4031941 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT192553 NZ_CP092452:c2604376-2604310 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References