Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3441634..3442291 Replicon chromosome
Accession NZ_CP069992
Organism Klebsiella pneumoniae strain FDAARGOS_1329

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K59_RS16810 Protein ID WP_002916310.1
Coordinates 3441634..3442044 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K59_RS16815 Protein ID WP_002916312.1
Coordinates 3442025..3442291 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K59_RS16790 3437634..3439367 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K59_RS16795 3439373..3440086 - 714 WP_004174456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K59_RS16800 3440109..3441005 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K59_RS16805 3441106..3441627 + 522 WP_004144730.1 flavodoxin FldB -
I6K59_RS16810 3441634..3442044 - 411 WP_002916310.1 protein YgfX Toxin
I6K59_RS16815 3442025..3442291 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K59_RS16820 3442537..3443520 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I6K59_RS16825 3443671..3444330 - 660 WP_002916317.1 hemolysin III family protein -
I6K59_RS16830 3444494..3444805 - 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
I6K59_RS16835 3444855..3445583 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K59_RS16840 3445702..3447135 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192550 WP_002916310.1 NZ_CP069992:c3442044-3441634 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192550 NZ_CP092452:1928062-1928165 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192550 WP_002916312.1 NZ_CP069992:c3442291-3442025 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192550 NZ_CP092452:c1928203-1927932 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References