Detailed information of TA system TA192541

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1615187..1616775
• Replicon: chromosome
• Accession: NZ_CP069992
• Organism: Klebsiella pneumoniae strain FDAARGOS_1329

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6K59_RS07965
• Protein ID: WP_032414910.1
• Coordinates: 1615453..1616775 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: I6K59_RS07960
• Protein ID: WP_002904790.1
• Coordinates: 1615187..1615453 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K59_RS07935	1610337..1611260	+	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-
I6K59_RS07940	1611241..1612395	-	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
I6K59_RS07945	1612741..1614120	+	1380	WP_004184021.1	purine permease	-
I6K59_RS07950	1614098..1614598	+	501	WP_032414907.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6K59_RS07955	1614595..1614921	+	327	WP_032414908.1	hydroxyisourate hydrolase	-
I6K59_RS07960	1615187..1615453	+	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K59_RS07965	1615453..1616775	+	1323	WP_032414910.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K59_RS07970	1616792..1618084	-	1293	WP_032414911.1	glycoside hydrolase family 10 protein	-
I6K59_RS07975	1618226..1619230	-	1005	WP_004176196.1	type 1 fimbrial protein	-
I6K59_RS07980	1619218..1621719	-	2502	WP_032414912.1	fimbrial biogenesis outer membrane usher protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49150.45 Da
• Isoelectric Point: 7.5618

>T192541 WP_032414910.1 NZ_CP069992:1615453-1616775 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGHDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T192541 NZ_CP092449:c4160250-4160077 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT192541 WP_002904790.1 NZ_CP069992:1615187-1615453 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT192541 NZ_CP092449:c4160574-4160278 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8