Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 3391626..3392551 Replicon chromosome
Accession NZ_CP069990
Organism Escherichia coli strain FDAARGOS_1304

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag I6K34_RS16590 Protein ID WP_014640052.1
Coordinates 3391626..3392012 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag I6K34_RS16595 Protein ID WP_024174200.1
Coordinates 3392042..3392551 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K34_RS16540 (3387133) 3387133..3387669 + 537 WP_021518223.1 5'-deoxynucleotidase -
I6K34_RS16545 (3387660) 3387660..3388538 + 879 WP_021518222.1 phosphoadenosine phosphosulfate reductase family protein -
I6K34_RS16550 (3388535) 3388535..3388738 + 204 WP_021518221.1 hypothetical protein -
I6K34_RS16555 (3388731) 3388731..3388970 + 240 WP_000476212.1 hypothetical protein -
I6K34_RS16560 (3388967) 3388967..3389521 + 555 WP_021518220.1 ead/Ea22-like family protein -
I6K34_RS16565 (3389523) 3389523..3389714 + 192 WP_001014291.1 hypothetical protein -
I6K34_RS26135 (3389717) 3389717..3390031 + 315 Protein_3281 DUF551 domain-containing protein -
I6K34_RS26140 (3390233) 3390233..3390475 + 243 Protein_3282 DUF551 domain-containing protein -
I6K34_RS16575 (3390475) 3390475..3391047 + 573 WP_001061345.1 3'-5' exonuclease -
I6K34_RS16580 (3391084) 3391084..3391365 + 282 WP_001093916.1 pyocin activator PrtN family protein -
I6K34_RS16585 (3391413) 3391413..3391586 - 174 WP_000390072.1 hypothetical protein -
I6K34_RS16590 (3391626) 3391626..3392012 - 387 WP_014640052.1 hypothetical protein Toxin
I6K34_RS16595 (3392042) 3392042..3392551 - 510 WP_024174200.1 Panacea domain-containing protein Antitoxin
I6K34_RS16600 (3393086) 3393086..3393601 + 516 WP_000416264.1 zinc uptake transcriptional repressor Zur -
I6K34_RS16605 (3393643) 3393643..3393852 - 210 WP_001296638.1 CsbD family protein -
I6K34_RS16610 (3393968) 3393968..3395293 - 1326 WP_001296637.1 MATE family efflux transporter DinF -
I6K34_RS16615 (3395366) 3395366..3395974 - 609 WP_000646078.1 transcriptional repressor LexA -
I6K34_RS16620 (3396084) 3396084..3396452 - 369 WP_000002899.1 diacylglycerol kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3334355..3404530 70175


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T192526 WP_014640052.1 NZ_CP069990:c3392012-3391626 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

>T192526 NZ_CP092449:729379-729675 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19559.39 Da        Isoelectric Point: 5.3338

>AT192526 WP_024174200.1 NZ_CP069990:c3392551-3392042 [Escherichia coli]
MAYLKLMKLLYLSNRKSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHDVLLRSDPREMDAD
EVFDELSRADIRILDEIYSLYGHMNRFDLANMTHLESVCPEWHNPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp

>AT192526 NZ_CP092449:729677-730072 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References