Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 669342..670173 Replicon chromosome
Accession NZ_CP069990
Organism Escherichia coli strain FDAARGOS_1304

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6K34_RS03205 Protein ID WP_000854814.1
Coordinates 669342..669716 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1PWQ3
Locus tag I6K34_RS03210 Protein ID WP_001285586.1
Coordinates 669805..670173 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K34_RS03165 (664738) 664738..665904 + 1167 WP_001297905.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
I6K34_RS03170 (666023) 666023..666496 + 474 WP_001105376.1 DNA gyrase inhibitor SbmC -
I6K34_RS03175 (666694) 666694..667752 + 1059 WP_001200890.1 FUSC family protein -
I6K34_RS03180 (667924) 667924..668253 + 330 WP_000450409.1 DUF496 family protein -
I6K34_RS03185 (668354) 668354..668488 - 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
I6K34_RS03190 (668590) 668590..668736 + 147 Protein_631 transposase domain-containing protein -
I6K34_RS03195 (669025) 669025..669105 - 81 Protein_632 hypothetical protein -
I6K34_RS03200 (669151) 669151..669345 - 195 WP_000988601.1 DUF5983 family protein -
I6K34_RS03205 (669342) 669342..669716 - 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
I6K34_RS03210 (669805) 669805..670173 - 369 WP_001285586.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K34_RS03215 (670247) 670247..670468 - 222 WP_000692323.1 DUF987 domain-containing protein -
I6K34_RS03220 (670537) 670537..671013 - 477 WP_001351157.1 RadC family protein -
I6K34_RS03225 (671029) 671029..671514 - 486 WP_000213703.1 antirestriction protein -
I6K34_RS03230 (671605) 671605..672426 - 822 WP_001234569.1 DUF932 domain-containing protein -
I6K34_RS03235 (672647) 672647..673057 - 411 WP_000846704.1 hypothetical protein -
I6K34_RS03240 (673073) 673073..673750 - 678 WP_001362823.1 hypothetical protein -
I6K34_RS03245 (673886) 673886..674956 - 1071 WP_000102631.1 patatin-like phospholipase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T192506 WP_000854814.1 NZ_CP069990:c669716-669342 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T192506 NZ_CP092442:c1139488-1139165 [Citrobacter portucalensis]
ATGCACATTTCATCTGTACCGGCCACGGTGCCGGTTTCGTCACGCCTGTCGCCCGTAATGGTGTGGCAGCAGCTGTTAAC
GTATCTGCTGGAGCACCACTACGGCCTGACACTCAACGACACACCATTTCATGACGACACGGCCATTGAGGAGCATATCG
ATGCGGGAATAACACTTGCCGATGCTGTTAATTTCCTGGTCGAAAAGTACGAACTGGCTCGTATCGACCGCAAGGGATTT
ACATGGCGAGAGCAACCCCCCTTCATTACTGCAACGGATATTCTGCGTGCCAAAAAGAACATCGGGCTGTTGCCCAGATC
TTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13563.41 Da        Isoelectric Point: 5.0468

>AT192506 WP_001285586.1 NZ_CP069990:c670173-669805 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELSPRYQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT192506 NZ_CP092442:c1139843-1139520 [Citrobacter portucalensis]
ATGCAAAATTCATGGGGACTGAAGCGCGACATCTCGCCGTGCTTCGGTGCAAGGCTTGTGCAGGAAGGCTGTCGCCTGCA
TTTTCTGGCGGACCGTGCAGGTATTAGTGGTACGTTTAACGAGGAGGAGGCACTGTGTCTGGATCAGGCATTTCCGCTAG
TGATGAAACAGCTTGAATTGATGCTGACAACCGGTGAACTGAATCCGCGCCATCAGCATTGCGTCACGTTGTATCATAAC
GGACTAACTTGTGAAGCTGACACTCTCGGCTCTCATGGCTATGTTTACATCGTTATTTATCCTCAGACATCTGCAACCCA
GTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB S1PWQ3

References