Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/RHH(antitoxin) |
| Location | 34716..35275 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP069982 | ||
| Organism | Escherichia coli strain FDAARGOS_1291 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | V0SVC8 |
| Locus tag | I6K21_RS24725 | Protein ID | WP_000421272.1 |
| Coordinates | 35000..35275 (+) | Length | 92 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | V0SRR3 |
| Locus tag | I6K21_RS24720 | Protein ID | WP_001387467.1 |
| Coordinates | 34716..35000 (+) | Length | 95 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K21_RS24695 (30179) | 30179..30619 | - | 441 | Protein_36 | zinc-binding dehydrogenase | - |
| I6K21_RS24700 (31020) | 31020..31910 | + | 891 | WP_001077068.1 | dihydrodipicolinate synthase family protein | - |
| I6K21_RS24705 (31935) | 31935..32315 | + | 381 | WP_000710783.1 | Rid family detoxifying hydrolase | - |
| I6K21_RS24710 (32348) | 32348..33313 | + | 966 | WP_001022265.1 | 2-keto-3-deoxygluconate transporter | - |
| I6K21_RS24715 (33359) | 33359..34111 | - | 753 | WP_000562172.1 | IclR family transcriptional regulator | - |
| I6K21_RS24720 (34716) | 34716..35000 | + | 285 | WP_001387467.1 | ribbon-helix-helix domain-containing protein | Antitoxin |
| I6K21_RS24725 (35000) | 35000..35275 | + | 276 | WP_000421272.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| I6K21_RS24730 (35381) | 35381..35584 | + | 204 | Protein_43 | hypothetical protein | - |
| I6K21_RS24735 (35709) | 35709..35837 | - | 129 | Protein_44 | IS481 family transposase | - |
| I6K21_RS24740 (35870) | 35870..37039 | - | 1170 | WP_001072355.1 | hypothetical protein | - |
| I6K21_RS24745 (37571) | 37571..37839 | + | 269 | Protein_46 | type II toxin-antitoxin system ParD family antitoxin | - |
| I6K21_RS25720 (37826) | 37826..38115 | + | 290 | Protein_47 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| I6K21_RS24750 (38182) | 38182..38364 | + | 183 | WP_042344623.1 | hypothetical protein | - |
| I6K21_RS24755 (38485) | 38485..39225 | + | 741 | WP_001066953.1 | tyrosine-type recombinase/integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Mobilizable plasmid | tet(B) / blaTEM-1B / aph(6)-Id / aph(3'')-Ib / sul2 / mph(A) / dfrA14 | - | 1..116491 | 116491 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10749.45 Da Isoelectric Point: 10.0871
>T192496 WP_000421272.1 NZ_CP069982:35000-35275 [Escherichia coli]
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
MELKWTSKALSDLSRLFDFLVLASKPAAARTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYEINGQTIY
VLRLWHTRENR
Download Length: 276 bp
>T192496 NZ_CP092435:c300275-299892 [Rhizobium sp. K102]
ATGGAAAATCTACCCCGCCCTACCCGACCGCTCCTTTGGATAGCGTCGAGCCGCAAAGACTATGCGGAGTTTCCGCCCAA
AGTGCAGGAAGCTTTTGGCTTTGAGCTGTTTCTGGCACAGACGGGGCAACACCCTCCATCGGCAAAGATGCTCAAGGGAC
TCGGCAATGGTATAGTGGAGCTGGTCGAAGACCACGACAGCGATACCTACCGCGCCGTTTATACGGTTCGTTTTGAAACG
GCCGTTTATGTGCTGCACTGCTTCAAGAAGAAGTCCAAGCGCGGCATCAAAACCCCTCAGAGCGATATCGAGCTGATCAA
GCACCGGTTCCGCGACGCGGAAGCCCATTATGCAGCCAAACAAAATGAGGAGCGCAAGCGATGA
ATGGAAAATCTACCCCGCCCTACCCGACCGCTCCTTTGGATAGCGTCGAGCCGCAAAGACTATGCGGAGTTTCCGCCCAA
AGTGCAGGAAGCTTTTGGCTTTGAGCTGTTTCTGGCACAGACGGGGCAACACCCTCCATCGGCAAAGATGCTCAAGGGAC
TCGGCAATGGTATAGTGGAGCTGGTCGAAGACCACGACAGCGATACCTACCGCGCCGTTTATACGGTTCGTTTTGAAACG
GCCGTTTATGTGCTGCACTGCTTCAAGAAGAAGTCCAAGCGCGGCATCAAAACCCCTCAGAGCGATATCGAGCTGATCAA
GCACCGGTTCCGCGACGCGGAAGCCCATTATGCAGCCAAACAAAATGAGGAGCGCAAGCGATGA
Antitoxin
Download Length: 95 a.a. Molecular weight: 10460.87 Da Isoelectric Point: 5.6558
>AT192496 WP_001387467.1 NZ_CP069982:34716-35000 [Escherichia coli]
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
MQMKNNAAQATKVITAHVPLPMADKVDQMAARLERSRGWVIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
SDSLSTDNPLPVPR
Download Length: 285 bp
>AT192496 NZ_CP092435:c299895-299557 [Rhizobium sp. K102]
ATGAAAACCGAACATGTCGAGGTTCATGCCGGCCACCCCAACATCTTTGCGGAGCTGGGGCTACCGGACGCCGAAAACCA
CTTCTTGAAAGCGCAGATTGTGGCGGCCCTGCACCGCCTCGTCAACGAGCGCAAACTCAACCAGGCCAAGGCCGGAACCA
TTATGGGCATCACTCAGCCGGAAGTGTCCCGCCTCTTCCGGGGGCATTTCCGGGAATACTCCGTTGAACGCCTCATGAGC
TTCCTGACAGCTTTCAACCAGGACGTTGAAATTGTCGTAAGGCCTCATGCCAAGGCCGGAGAAGCCGGCAACATAACCTT
CAATGCCGTCACGGCTTAA
ATGAAAACCGAACATGTCGAGGTTCATGCCGGCCACCCCAACATCTTTGCGGAGCTGGGGCTACCGGACGCCGAAAACCA
CTTCTTGAAAGCGCAGATTGTGGCGGCCCTGCACCGCCTCGTCAACGAGCGCAAACTCAACCAGGCCAAGGCCGGAACCA
TTATGGGCATCACTCAGCCGGAAGTGTCCCGCCTCTTCCGGGGGCATTTCCGGGAATACTCCGTTGAACGCCTCATGAGC
TTCCTGACAGCTTTCAACCAGGACGTTGAAATTGTCGTAAGGCCTCATGCCAAGGCCGGAGAAGCCGGCAACATAACCTT
CAATGCCGTCACGGCTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | V0SVC8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E0Y880 |