Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 79899..80730 Replicon chromosome
Accession NZ_CP069980
Organism Escherichia coli strain FDAARGOS_1291

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag I6K21_RS00330 Protein ID WP_000854814.1
Coordinates 80356..80730 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag I6K21_RS00325 Protein ID WP_001285585.1
Coordinates 79899..80267 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K21_RS00290 (75885) 75885..76727 + 843 Protein_56 hypothetical protein -
I6K21_RS00295 (76803) 76803..77258 + 456 WP_000581504.1 IrmA family protein -
I6K21_RS00300 (77337) 77337..77570 + 234 WP_001119729.1 DUF905 family protein -
I6K21_RS00305 (77670) 77670..78488 + 819 WP_021538423.1 DUF932 domain-containing protein -
I6K21_RS00310 (78570) 78570..79049 + 480 WP_000860087.1 antirestriction protein -
I6K21_RS00315 (79065) 79065..79541 + 477 WP_001186726.1 RadC family protein -
I6K21_RS00320 (79604) 79604..79825 + 222 WP_000692323.1 DUF987 domain-containing protein -
I6K21_RS00325 (79899) 79899..80267 + 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
I6K21_RS00330 (80356) 80356..80730 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
I6K21_RS00335 (80727) 80727..80921 + 195 WP_000988600.1 DUF5983 family protein -
I6K21_RS00340 (80967) 80967..81047 + 81 Protein_66 hypothetical protein -
I6K21_RS00345 (81336) 81336..81464 - 129 Protein_67 transposase domain-containing protein -
I6K21_RS00350 (81584) 81584..81718 + 135 WP_230887339.1 EutP/PduV family microcompartment system protein -
I6K21_RS00355 (81819) 81819..82148 - 330 WP_000450409.1 DUF496 family protein -
I6K21_RS00360 (82320) 82320..83378 - 1059 WP_001200891.1 FUSC family protein -
I6K21_RS00365 (83576) 83576..84049 - 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
I6K21_RS00370 (84168) 84168..85334 - 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T192461 WP_000854814.1 NZ_CP069980:80356-80730 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T192461 NZ_CP092412:c1230700-1229954 [Bacillus velezensis]
ATGCTTTTGTTTTTTCAGATTATGGTGTGGACGATGGCGGCCGCACTCATTTTATATGTGTACGCATCCTGGCGGTATGA
GGCAAAGGTAAAAGAAAAAATGTTTGCCATCCGTAAAACGTGGTATTTACTATTTGTACTGGGCTCCATGGTCTATTGGA
CATATGATCCCGAATCGCTCTTTGCCGAATGGAGACAATATTTGATTGTTGCCGTCTGCTTTGCCCTTATTGATGCGTTT
ATCTTTTTGAGCGCGTATATCAAAAAGCTCGCCGGCAATGAATTAGAGACGGATACGCGGGAAATTTTAGAAGAAAATAA
CGAAATGCTTCACTCCTATCTTGAAAAACTGAAAACCTATCAATATCTGTTGAAAAATGAACCGATCCATGTATATTATG
GAAGTACAGAAGCTTATGCGGAAGGCATCAGCAGACTGCTGGCCGCTTATGCCGAAAAAATGAATGTCACGGCTTCCTTG
TGCGACTATTCCGCACAAGCGGATAAGGACCGCTTGACAGAGCATATGCCTGATGCGGCGGACGTTCAGTCCCGTCTTAA
CCGTAAAGACGTCTACTATGATCAAAAAGGCAGGCTTGTGCTTATTCCGTTTACAGTTCAGAACCGCCATTACGTGATCA
AACTCACGTCGGAAAACCTGTTGACGGAATTCGATTATTTGCTTTTCACATCGCTAACGAGCATTTATGATTTAATGCTG
CCAATAGAAGAGGAAGGTGACGGTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT192461 WP_001285585.1 NZ_CP069980:79899-80267 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT192461 NZ_CP092412:c1229953-1229783 [Bacillus velezensis]
ATGGAGCAGGCATTTCAAAACGGGCAGCCGGAACAAAGAGCGAAACCGTTCAAAATGTTTAAAAAACGTTCAATGACAAG
TATCGCAAGTTACCAGGTCAGCCCTCATACCGCCAGAATTTTCAAAGAAAACGAGCGGCTGATTGACAAGTATAAACAAA
AAAAAGCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References