Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3881093..3881619 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag I6K10_RS19515 Protein ID WP_000323025.1
Coordinates 3881093..3881380 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag I6K10_RS19520 Protein ID WP_000534858.1
Coordinates 3881380..3881619 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS19470 (3876177) 3876177..3876635 - 459 WP_000526135.1 IS200/IS605-like element IS200C family transposase -
I6K10_RS19475 (3877086) 3877086..3877301 - 216 WP_000066484.1 cold shock-like protein CspB -
I6K10_RS19480 (3877602) 3877602..3877814 + 213 WP_000087756.1 cold shock-like protein CspF -
I6K10_RS19485 (3877869) 3877869..3877958 + 90 WP_120795389.1 hypothetical protein -
I6K10_RS19490 (3878236) 3878236..3878988 - 753 WP_001047135.1 antitermination protein -
I6K10_RS19495 (3879002) 3879002..3880051 - 1050 WP_001265199.1 DUF968 domain-containing protein -
I6K10_RS19500 (3880053) 3880053..3880331 - 279 WP_012304870.1 hypothetical protein -
I6K10_RS19505 (3880398) 3880398..3880649 - 252 WP_000980994.1 protein Rem -
I6K10_RS19510 (3880866) 3880866..3881021 - 156 WP_000813254.1 type I toxin-antitoxin system toxin HokD -
I6K10_RS19515 (3881093) 3881093..3881380 - 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
I6K10_RS19520 (3881380) 3881380..3881619 - 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
I6K10_RS19525 (3881644) 3881644..3881949 + 306 WP_001326990.1 protein YdfV -
I6K10_RS19530 (3882152) 3882152..3882484 + 333 WP_001301033.1 FlxA-like family protein -
I6K10_RS27110 (3882921) 3882921..3883070 - 150 WP_011443592.1 protein YdfW -
I6K10_RS19535 (3883191) 3883191..3884213 - 1023 Protein_3658 ISNCY family transposase -
I6K10_RS19540 (3884718) 3884718..3885740 - 1023 WP_251301666.1 DUF4868 domain-containing protein -
I6K10_RS19545 (3885743) 3885743..3886357 - 615 WP_001265627.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 3848200..3899921 51721
- flank IS/Tn - - 3876177..3876635 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T192413 WP_000323025.1 NZ_CP069973:c3881380-3881093 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

>T192413 NZ_CP092380:225872-226024 [Xanthomonas oryzae]
ATGAAGCGACTGCTGACACTGATGGTGCTGGGCCTGTTTTCGGCCGGCGTGATGACGGGCTGCAACACCGTGGCTGGCGC
TGGCAAGGACTTGCAGGGCGCGGGTGGGAAGGTCGAGAAAACGGCCGAAAAATGCAGCGATGGTAAGTGCTGA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT192413 WP_000534858.1 NZ_CP069973:c3881619-3881380 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp

>AT192413 NZ_CP092380:226088-226222 [Xanthomonas oryzae]
ATGAAGCGTGCAATTGTGCTGCTCGTGCTGTCCATGTTGTCGGTCGGTCTGCTGTCGGGCTGCAACACCGTCGCAGGTGC
CGGCAAGGACGTGAAGGGCGCCGGCGAGAAGGTGGAAGACGCAGCGCGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References