192404

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3262118..3262902 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name TacT2 Uniprot ID V0T0H9
Locus tag I6K10_RS16355 Protein ID WP_000613626.1
Coordinates 3262118..3262612 (-) Length 165 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID L4JCW6
Locus tag I6K10_RS16360 Protein ID WP_001110447.1
Coordinates 3262609..3262902 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS16335 (3257311) 3257311..3258408 + 1098 WP_000589326.1 flagellar basal body P-ring protein FlgI -
I6K10_RS16340 (3258408) 3258408..3259349 + 942 WP_001522863.1 flagellar assembly peptidoglycan hydrolase FlgJ -
I6K10_RS16345 (3259415) 3259415..3261058 + 1644 WP_001522865.1 flagellar hook-associated protein FlgK -
I6K10_RS16350 (3261070) 3261070..3262023 + 954 WP_001212768.1 flagellar hook-associated protein FlgL -
I6K10_RS16355 (3262118) 3262118..3262612 - 495 WP_000613626.1 GNAT family N-acetyltransferase Toxin
I6K10_RS16360 (3262609) 3262609..3262902 - 294 WP_001110447.1 DUF1778 domain-containing protein Antitoxin
I6K10_RS16365 (3263035) 3263035..3266220 - 3186 WP_001522867.1 ribonuclease E -
I6K10_RS16370 (3266793) 3266793..3267752 + 960 WP_000846343.1 23S rRNA pseudouridine(955/2504/2580) synthase RluC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(81-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 165 a.a.        Molecular weight: 18084.00 Da        Isoelectric Point: 8.2617

>T192404 WP_000613626.1 NZ_CP069973:c3262612-3262118 [Escherichia coli]
MIQAPEPLMARHQFTSFCSGVETMDNWLKQRALKNQLAGASRTFVSCDTYSNVLAYYSLASSAVETYVATGRFRRNMPEP
IPVVVLGRLAIDKSLQGQGIGRAMVRDAGLRVLQAAEVIGIRGMLVHALSDQAREFYLRVGFEPSPVDSMILMATLADLQ
ECLK

Download         Length: 495 bp

>T192404 NZ_CP092373:3373323-3373655 [Pantoea sp. Z09]
ATGGAGCGCGGCGAAATCTGGCTGGTCTCACTTGATCCCACTGCCGGTCATGAGCAACAGGGCACGCGGCCAGTATTAAT
CGTTTCGCCTGCGGCCTTCAACCAGCTAACCCAAACGCCTGTCGTACTGCCTGTCACAACCGGCGGGAATTTCGCTCGTA
CTGCGGGATTTACTGTTTCGCTTGATACGGCAGGAACGCGGACGCGTGGTGTTATTCGCTGCGATCAGCCGCGTGCAATT
GATATGCGCGCGCGTCATGGTAAACGGCTGGAGCACATTCCAGCCGACTTGATGGCAGAGGTGCAGGCGATTTTGCGTGC
GATACTGAGTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11109.69 Da        Isoelectric Point: 10.5423

>AT192404 WP_001110447.1 NZ_CP069973:c3262902-3262609 [Escherichia coli]
MPAANNIPTRRESLNLRIKPAERDLIDRAAKARGKNRTEFVLEAARAAAEEALIEQRIFRIDSDDYQLFLNRLDQPPAPN
AALRKTMQTPAPWEQKK

Download         Length: 294 bp

>AT192404 NZ_CP092373:3373066-3373323 [Pantoea sp. Z09]
ATGCACACGACTCATCTCCGTAAAGTGGGCGGTTCCGTCATGCTGGCTGTTCCGCCTGCTCTGCTTGATATTCTTCAACT
CAGTGCCGACGCACAGGTTGGCCTGACGGTCGATAACGGACGTCTGATTATTGAACCTAAAACTGTACCCAGTTATACGC
TGGCTGAGTTGCTGGCTAAATGTGATCCAGAAGCGGAACTGACTGCTGAAGATCGGCTGTGGATTGATGCCGTACCGGTG
GGGAAAGAGGAACTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0T0H9

Antitoxin

Source ID Structure
AlphaFold DB L4JCW6

References