Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2551537..2552155 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag I6K10_RS13085 Protein ID WP_001291435.1
Coordinates 2551537..2551755 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag I6K10_RS13090 Protein ID WP_000344800.1
Coordinates 2551781..2552155 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS13050 (2546826) 2546826..2547398 + 573 WP_000779831.1 YbaY family lipoprotein -
I6K10_RS13055 (2547429) 2547429..2547740 - 312 WP_000409911.1 MGMT family protein -
I6K10_RS13065 (2548119) 2548119..2548472 + 354 WP_000878140.1 DUF1428 domain-containing protein -
I6K10_RS13070 (2548514) 2548514..2550064 - 1551 WP_001577872.1 cyclic-guanylate-specific phosphodiesterase PdeB -
I6K10_RS13075 (2550228) 2550228..2550698 - 471 WP_001490888.1 YlaC family protein -
I6K10_RS13080 (2550814) 2550814..2551365 - 552 WP_001522034.1 maltose O-acetyltransferase -
I6K10_RS13085 (2551537) 2551537..2551755 - 219 WP_001291435.1 HHA domain-containing protein Toxin
I6K10_RS13090 (2551781) 2551781..2552155 - 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
I6K10_RS13095 (2552701) 2552701..2555850 - 3150 WP_001132480.1 efflux RND transporter permease AcrB -
I6K10_RS13100 (2555873) 2555873..2557066 - 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192402 WP_001291435.1 NZ_CP069973:c2551755-2551537 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T192402 NZ_CP092373:1626503-1626602 [Pantoea sp. Z09]
GCAAGGCGACATCGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCAACGAGCCATTTCCCTGGACCGAATACAGGA
ATCGTGTTCGGTCTTTTTTT

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT192402 WP_000344800.1 NZ_CP069973:c2552155-2551781 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp

>AT192402 NZ_CP092373:c1626602-1626503 [Pantoea sp. Z09]
AAAAAAAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAATGGCTCGTTGAGAGCCGTGCGCTAAAAGTTGGCATTAA
TGCAGGCGATGTCGCCTTGC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References