Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1841225..1841747 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag I6K10_RS09740 Protein ID WP_001105433.1
Coordinates 1841457..1841747 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6K10_RS09735 Protein ID WP_000212715.1
Coordinates 1841225..1841467 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS09715 (1836941) 1836941..1838314 + 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -
I6K10_RS09720 (1838466) 1838466..1839017 - 552 WP_000166270.1 ribosome biogenesis factor YjgA -
I6K10_RS09725 (1839111) 1839111..1840463 + 1353 WP_001162173.1 metalloprotease PmbA -
I6K10_RS09730 (1840647) 1840647..1841033 + 387 WP_001232246.1 cytochrome b562 -
I6K10_RS09735 (1841225) 1841225..1841467 + 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K10_RS09740 (1841457) 1841457..1841747 + 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K10_RS09745 (1841748) 1841748..1842212 - 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K10_RS09750 (1842397) 1842397..1844535 - 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
I6K10_RS09755 (1844929) 1844929..1846584 - 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T192398 WP_001105433.1 NZ_CP069973:1841457-1841747 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T192398 NZ_CP092373:c490573-490223 [Pantoea sp. Z09]
ATGTGGACTGTGCTTTTCGGCGAGATATTCGATGCGTGGTTCGAAGACCAGGAAGAAGCTTTGCAGGAAAAAATCCTTGC
CGACCTCATCAACCTCAGGACGTATGGACCCACGCTGCCTCGGCCTTATGCGGATACGGTTAAAGGATCGCGACACAAGA
ATATGAAAGAACTTCGTATTCAATACGCAGGAAAGCCGGTACGCGCCTTTTTCGCGTTTGATCCCGTGCGCAGAGCGGTC
ATTCTTTGCGCAGGTGATAAAAGCAATGATAAAAATTTTTACCCGCGCATGATACGTATCGCCGACGATGCATTTACGGC
GCACCTGAACAATATGAAGGGGAAACTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT192398 WP_000212715.1 NZ_CP069973:1841225-1841467 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT192398 NZ_CP092373:c490226-489927 [Pantoea sp. Z09]
ATGAGAACACTCGATGATGCTATTGCTGCACGCTCTGCGGAAAGCCAGCAGCGCATACGCGATATGGCAGACGAGATGGT
GCTCGAAACCGGCCTGCAGATGATGCGAGAAGAACTGCAACTGTCGCAAAAAAACGTTGCGGAAGCGATGGGCATCAGCC
AGCCCGCGATTACGCAGCTAGAGCAACGCGGCAACGAGCTGAAAATTGCGACGCTTAAGCGCTACATTGAGGCAATGGGA
GGTAAGCTCAGCCTGGATGTGGAATTGCCTTCCGGCAAACGCATCGCTTTTCACCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References