Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 236960..237620 Replicon chromosome
Accession NZ_CP069973
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag I6K10_RS02120 Protein ID WP_029701967.1
Coordinates 236960..237373 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag I6K10_RS02125 Protein ID WP_000354046.1
Coordinates 237354..237620 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS02100 (232924) 232924..234657 - 1734 WP_029701971.1 single-stranded-DNA-specific exonuclease RecJ -
I6K10_RS02105 (234663) 234663..235373 - 711 WP_029701969.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K10_RS02110 (235397) 235397..236293 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
I6K10_RS02115 (236405) 236405..236926 + 522 WP_001055874.1 flavodoxin FldB -
I6K10_RS02120 (236960) 236960..237373 - 414 WP_029701967.1 protein YgfX Toxin
I6K10_RS02125 (237354) 237354..237620 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
I6K10_RS02130 (237863) 237863..238843 + 981 WP_000886083.1 tRNA-modifying protein YgfZ -
I6K10_RS02135 (238920) 238920..239579 - 660 WP_000250274.1 hemolysin III family protein -
I6K10_RS02140 (239743) 239743..240054 - 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
I6K10_RS02145 (240099) 240099..241532 + 1434 WP_001336277.1 6-phospho-beta-glucosidase BglA -
I6K10_RS02150 (241589) 241589..242332 - 744 WP_000951964.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16305.25 Da        Isoelectric Point: 11.7064

>T192390 WP_029701967.1 NZ_CP069973:c237373-236960 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLLHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQRSR

Download         Length: 414 bp

>T192390 NZ_CP092369:c2184948-2184697 [Bacillus subtilis]
ATGAACTTCTCCTTTAGTTCCTACCCATATTATAACATGATCAAGCACATTGCAAACATGAAACGATTCTCATTATGGTT
TACTCATATCACTTTCATTGGCTTATTCTTAATGTTTCAACTCATTAAGGATTACTTCAGCAACGAAGCACAAACACTAA
TCAATACAATTTTTGTAGTCACGTGTATCATTGCCATATTGTTGTGGATCATCTATTTTGTATTCCTTAAACTAAGAAAC
AAGTCACACTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT192390 WP_000354046.1 NZ_CP069973:c237620-237354 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192390 NZ_CP092369:2184926-2185026 [Bacillus subtilis]
TAGGAACTAAAGGAGAAGTTCATTCCCCTTTAGCTTAGCTCTCATCGGCGTATATGTTGGCGTTGTCTCTTTGGTCGGAG
CCGCTTGCGTATACGCTTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References