Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 1562..2205 Replicon plasmid unnamed1
Accession NZ_CP069970
Organism Escherichia coli strain FDAARGOS_1280

Toxin (Protein)


Gene name vagD Uniprot ID B1LRW4
Locus tag I6K10_RS00015 Protein ID WP_001044768.1
Coordinates 1789..2205 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D2WFK3
Locus tag I6K10_RS00010 Protein ID WP_001261287.1
Coordinates 1562..1792 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K10_RS00005 (I6K10_00005) 1..1255 - 1255 Protein_0 hypothetical protein -
I6K10_RS00010 (I6K10_00010) 1562..1792 + 231 WP_001261287.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
I6K10_RS00015 (I6K10_00015) 1789..2205 + 417 WP_001044768.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K10_RS00020 (I6K10_00020) 2367..4505 - 2139 WP_000350635.1 AAA family ATPase -
I6K10_RS00025 (I6K10_00025) 4970..5965 + 996 WP_000246636.1 hypothetical protein -
I6K10_RS00030 (I6K10_00030) 5969..6901 + 933 WP_000991832.1 S-4TM family putative pore-forming effector -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..39407 39407
- flank IS/Tn - - 7038..7541 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15197.66 Da        Isoelectric Point: 7.7805

>T192381 WP_001044768.1 NZ_CP069970:1789-2205 [Escherichia coli]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHVQLVDEFCARLDAILPWDRA
AVDATTKIKVALRLAGTPIGPNDTAIAGHAIAAGAILVTNNTREFERVPDLVLEDWVK

Download         Length: 417 bp

>T192381 NZ_CP092362:c2970989-2970591 [Mycolicibacterium crocinum]
TTGATGCAGGTCTACCTCGACACCTCCGCTTTGATGAAACTCGTGGTCCTCGAGCCCGAAACATCAGCACTACGAACGTA
TTTGACACAGTATCCCGACGATGTTCGGTTCACGGCGGCGCTGTCGCGTACCGAGTTGCTCAGGGCAGCCCGGCGCAGCG
GCTCGTATGAGCTTGCCGCACAAGCTCACCGACTGCTGGGCCGACTCGACTTGGTTGCAATGACTACCCGGCTGCTGGAC
GAAGCCGGCACACTCGGACCGCCTGAGCTGAGGACGCTGGACGCGATCCACTTGGCGGCCGCGCGTACCGCGCCTGCTTT
GCGGGGCCTTGTCACATACGACCTCCGGCTTGCGGCGGCCGCCGAAGCCGTCGGCATCACCGTCGCGATCCCGCAATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8815.90 Da        Isoelectric Point: 4.3775

>AT192381 WP_001261287.1 NZ_CP069970:1562-1792 [Escherichia coli]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFLEYEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT192381 NZ_CP092362:c2971252-2970986 [Mycolicibacterium crocinum]
ATGGAGCGCATCGGGCTGCGAGAGCTGCGCCAGCATGCGAGCCAGTATGTCGACCGAGCAGCGGGCGGCGAATCCATCGA
AATCACCGTCCGTGGGCGACTGGTAGCCATGCTGGTGCCCGCTGGTGAGGGAACCTGGGACGACCTGATTGTGCGCGGTG
AGGTGCTACCGGCTCCGGCGCGCCTGGATCTGCTCGACGAACCGGCGCGGGACTACGGATTCGACGCATCAGAATCCTTG
CGTCGACTTCGGGACCACGAACGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A606Q844

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QFC4

References