Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 184121..184857 Replicon plasmid unnamed2
Accession NZ_CP069969
Organism Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)


Gene name tacT Uniprot ID L7SZ15
Locus tag I6K38_RS26825 Protein ID WP_003026803.1
Coordinates 184375..184857 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID L7SZ29
Locus tag I6K38_RS26820 Protein ID WP_003026799.1
Coordinates 184121..184387 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K38_RS26770 179921..180355 + 435 WP_004118347.1 hypothetical protein -
I6K38_RS26775 180734..180832 - 99 WP_004118688.1 type II toxin-antitoxin system RelE/ParE family toxin -
I6K38_RS26780 180819..180998 - 180 WP_004118349.1 type II toxin-antitoxin system ParD family antitoxin -
I6K38_RS26785 181312..181575 + 264 WP_004118691.1 hypothetical protein -
I6K38_RS26790 181572..182138 + 567 WP_029497543.1 hypothetical protein -
I6K38_RS26795 182169..182663 + 495 WP_009310053.1 hypothetical protein -
I6K38_RS26800 182707..183075 + 369 WP_009310054.1 hypothetical protein -
I6K38_RS26805 183106..183309 + 204 WP_004098931.1 hemolysin expression modulator Hha -
I6K38_RS26810 183358..183615 + 258 WP_004098928.1 hypothetical protein -
I6K38_RS26815 183691..183945 + 255 WP_004118702.1 hypothetical protein -
I6K38_RS26820 184121..184387 + 267 WP_003026799.1 DUF1778 domain-containing protein Antitoxin
I6K38_RS26825 184375..184857 + 483 WP_003026803.1 GNAT family N-acetyltransferase Toxin
I6K38_RS26830 185016..186270 - 1255 Protein_198 IS3 family transposase -
I6K38_RS26835 186358..187320 - 963 WP_004152113.1 M48 family metalloprotease -
I6K38_RS26840 187307..187795 - 489 WP_004152114.1 phosphate-starvation-inducible PsiE family protein -
I6K38_RS26845 188293..188490 - 198 WP_004152115.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..198770 198770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(6-82)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17353.97 Da        Isoelectric Point: 9.5822

>T192380 WP_003026803.1 NZ_CP069969:184375-184857 [Klebsiella pneumoniae]
VGRITTPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

>T192380 NZ_CP069969:184375-184857 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10147.59 Da        Isoelectric Point: 4.5256

>AT192380 WP_003026799.1 NZ_CP069969:184121-184387 [Klebsiella pneumoniae]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp

>AT192380 NZ_CP069969:184121-184387 [Klebsiella pneumoniae]
ATGAAATCAGATGTTCAACTCAACCTAAGAGCTAAAGAGTCTCAGAGAGCACTCATCGATGCTGCTGCAGAGATCCTTCA
TAAATCGCGAACCGACTTTATCCTGGAGATGGCCTGCAAGGCTGCGGAGAATGTGATCCTTGATCGCCGTGTTTTCAATT
TTAACGACGAACAGTATGCAGAGTTCATCGATATGCTCGATGCACCAGTCGAGGATGAGCCCGCCATTAATAAACTACTG
GCAAGGAAACCTCAGTGGGACGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0J2GNW6

Antitoxin

Source ID Structure
AlphaFold DB A0A1Q8YL66

References