Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 153653..154296 Replicon plasmid unnamed2
Accession NZ_CP069969
Organism Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)


Gene name vagD Uniprot ID D8L2J9
Locus tag I6K38_RS26655 Protein ID WP_001044770.1
Coordinates 153880..154296 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID D5KTK7
Locus tag I6K38_RS26650 Protein ID WP_001261282.1
Coordinates 153653..153883 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K38_RS26625 149312..149569 - 258 WP_040251913.1 hypothetical protein -
I6K38_RS26630 150173..151627 + 1455 WP_071836382.1 EAL domain-containing protein -
I6K38_RS26635 152161..152691 - 531 Protein_159 hypothetical protein -
I6K38_RS26640 152743..153093 - 351 WP_023328272.1 hypothetical protein -
I6K38_RS26645 153282..153696 - 415 Protein_161 hypothetical protein -
I6K38_RS26650 153653..153883 + 231 WP_001261282.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
I6K38_RS26655 153880..154296 + 417 WP_001044770.1 type II toxin-antitoxin system VapC family toxin Toxin
I6K38_RS26660 154370..155932 + 1563 WP_004206609.1 AAA family ATPase -
I6K38_RS26665 155917..156939 + 1023 WP_000361404.1 helicase UvrD -
I6K38_RS26670 157477..158391 + 915 WP_031592169.1 HNH endonuclease -
I6K38_RS26675 158577..158927 - 351 WP_064279361.1 DUF305 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..198770 198770


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-47)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15106.52 Da        Isoelectric Point: 7.1084

>T192379 WP_001044770.1 NZ_CP069969:153880-154296 [Klebsiella pneumoniae]
VNKTYMLDTCICSFIMREQPEAVLKRLEQAVLRGQRIVVSAITYSEMRFGATGPKASPRHVELVDAFCARLDAILPWDRA
AVDATTEIKVALRMAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWVR

Download         Length: 417 bp

>T192379 NZ_CP092362:1052685-1053068 [Mycolicibacterium crocinum]
GTGACCGAATACTTGGACCGCGACGATGTTCTGGTCGCAGGTGCTGCGGCGGTGGGGGTCGAGCTGAGGGTGGCCGACTA
CGGCCTGCTCGACGCGGCGGTGGCGCGACCGCAGGCCACAGCCTTCGGCGTTGACGCCTATCCGGACCTGTTCACCAAGG
CGGCGGCGCTGCTGCACTCTCTGGCGCGTAACCACGCTCTGGTCGACGGCAACAAGCGCACCGCGTGGGCCGCCGCATGG
ACTTTTCTGTACATCAACGGAGTCGAATTAGATCCGGATTTCGATGTCGACGACGCGGAGGATTTCATGAATGCTGTTGC
TGTCCAAGGTGATCTGCAACTGGCGGAAATTGGGCAGACGCTGCAAGCATTCGCGGACGGATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8756.83 Da        Isoelectric Point: 4.4692

>AT192379 WP_001261282.1 NZ_CP069969:153653-153883 [Klebsiella pneumoniae]
MRTVSIFKNGNNRAIRLPRDLDFEGVSELEIVREGDSIILRPVRPTWGSFAQFEKADPDFMAEREDVVSDEGRFNL

Download         Length: 231 bp

>AT192379 NZ_CP092362:1052491-1052688 [Mycolicibacterium crocinum]
ATGCCAGCCTTGAACGTCAACTTCAGCGACGCCGAGATGGAACAGTTGCGCACCGCGGCGGCTGCGGGGGAGCTGTCGTT
GCGCGCGTTCGTGCACCGCGCCGCCCTCGATGCCGCGAGCGACCACAAGCGTCGCGTGCGGGAAGGGGCGCGGATCGTCG
CCGAGCGCAGCGCAGAGCTCAACCGTCGGCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYM2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GZG3

References