Detailed information of TA system TA192378

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4776366..4777023
• Replicon: chromosome
• Accession: NZ_CP069968
• Organism: Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: I6K38_RS23350
• Protein ID: WP_004181233.1
• Coordinates: 4776613..4777023 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W8UQ37
• Locus tag: I6K38_RS23345
• Protein ID: WP_002916312.1
• Coordinates: 4776366..4776632 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K38_RS23320	4771522..4772955	-	1434	WP_004181234.1	6-phospho-beta-glucosidase	-
I6K38_RS23325	4773074..4773802	-	729	WP_002916321.1	MurR/RpiR family transcriptional regulator	-
I6K38_RS23330	4773852..4774163	+	312	WP_004144734.1	N(4)-acetylcytidine aminohydrolase	-
I6K38_RS23335	4774327..4774986	+	660	WP_002916317.1	hemolysin III family protein	-
I6K38_RS23340	4775137..4776120	-	984	WP_002916313.1	tRNA-modifying protein YgfZ	-
I6K38_RS23345	4776366..4776632	+	267	WP_002916312.1	FAD assembly factor SdhE	Antitoxin
I6K38_RS23350	4776613..4777023	+	411	WP_004181233.1	protein YgfX	Toxin
I6K38_RS23355	4777030..4777551	-	522	WP_004144730.1	flavodoxin FldB	-
I6K38_RS23360	4777652..4778548	+	897	WP_004144729.1	site-specific tyrosine recombinase XerD	-
I6K38_RS23365	4778571..4779284	+	714	WP_002916301.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
I6K38_RS23370	4779290..4781023	+	1734	WP_004149758.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16121.92 Da
• Isoelectric Point: 11.1565

>T192378 WP_004181233.1 NZ_CP069968:4776613-4777023 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAEEWRDLRRLVLQKPAQE

Nucleotide

• Length: 411 bp

>T192378 NZ_CP092361:1894341-1894619 [Wielerella bovis]
ATGTATGCGATTTCATTTGATTTGGTCGTTTCCGACACCCAAAATGCCCACCCAAAAGGCGTAAGCCAAGCCTATCAAGA
TATTGGCGCAACCCTACATCAATACGGTTTTGAGCGCGTTCAAGGCAGCCTGTATATCAATGACAATGAAGACATGGCAA
ACCTGTTTTCTGCCATTCAAGCCTTGAAAAATTTGGCGTGGTTTCCCACTTCTGTGCGTGATATTCGCGCATTCCGCATT
GAGCAATGGTCGGATTTTACAAAATTTGTGAAAACCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10480.98 Da
• Isoelectric Point: 5.1116

>AT192378 WP_002916312.1 NZ_CP069968:4776366-4776632 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT192378 NZ_CP092361:1894146-1894337 [Wielerella bovis]
ATGATAAATCAACAGAATATTCCAACTGGCGAAGTGCGGACTTTTGGCACATTTGGCGTGCCTTATTTGGTCGGCAAAGC
GGAACAGGAATTGCCCAATGGCGACATTTTGGTGGGCATTGAATTGTTGGAAAGTGGCGAGCATGAACAATATCCGCTCT
CCCATTTGTTGCAAGACCCGAAAGCCAATTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GY41