Detailed information of TA system TA192375

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3593183..3594864
• Replicon: chromosome
• Accession: NZ_CP069968
• Organism: Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: I6K38_RS17640
• Protein ID: WP_004178299.1
• Coordinates: 3593183..3594100 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: I6K38_RS17645
• Protein ID: WP_004177809.1
• Coordinates: 3594106..3594864 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K38_RS17620	3588489..3590009	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
I6K38_RS17625	3590006..3591004	+	999	WP_002885172.1	ribose ABC transporter permease	-
I6K38_RS17630	3591035..3591976	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K38_RS17635	3592051..3593058	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
I6K38_RS17640	3593183..3594100	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K38_RS17645	3594106..3594864	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6K38_RS17650	3594950..3595678	-	729	WP_004178298.1	response regulator transcription factor	-
I6K38_RS17655	3595951..3598098	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6K38_RS17660	3598328..3599014	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T192375 WP_004178299.1 NZ_CP069968:c3594100-3593183 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T192375 NZ_CP092360:c1703783-1703454 [Wielerella bovis]
ATGGAGCGTGGCGATATTTTTCTGGTCAATTTAGACCCCACAACAGGGCATGAACAACAAGGCACACGCCCAGTTCTCAT
TATTTCCCCGAAAGCATTCAATGCTTTAACCCAAGTGCCGATTGTTTTGCCGATTACGACCAAAAGCCAATTTGCGCGAA
CGCAAGGTTTTGCCGTGCATTTGGACGAGCGTACCAAAACGCAAGGCATTGTCCGCACAGACCAGTCACGCGCTTTGGAT
ATTCAGGCGCGAAATGGCAGGAAATTGGAAACCTTACCGATTGATTTAATGAATGAAGTGTTGGCAAAAATGGCGACTTT
TTTAAGCTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT192375 WP_004177809.1 NZ_CP069968:c3594864-3594106 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT192375 NZ_CP092360:c1704035-1703790 [Wielerella bovis]
ATGTACACCGTTTCCCTACGCAAAGTTGGCGGTTCAACCATGCTTGCCATTCCACCAGCTTTATTGCAAAGCCTTGATTT
GGGAAAACAAGTTCATTTGCATACCGAAAATGGACGTTTGATTATTGAGCCAGCGCGTCCCCAATACACTTTGGCGGAAT
TGCTCGCACAATGCGACCCCAACGCGCCACGCGATGTGGAAAGTCAAACGTGGTTGGACGCGCCTGCCGTTGGGCAAGAA
TGGTAA

Structures

Antitoxin

• AlphaFold DB: A6TH05