Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2732294..2732913 Replicon chromosome
Accession NZ_CP069968
Organism Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K38_RS13580 Protein ID WP_002892050.1
Coordinates 2732695..2732913 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K38_RS13575 Protein ID WP_002892066.1
Coordinates 2732294..2732668 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K38_RS13565 2727446..2728639 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6K38_RS13570 2728662..2731808 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K38_RS13575 2732294..2732668 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K38_RS13580 2732695..2732913 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K38_RS13585 2733072..2733638 + 567 WP_002892030.1 maltose O-acetyltransferase -
I6K38_RS13590 2733610..2733750 - 141 WP_004147370.1 hypothetical protein -
I6K38_RS13595 2733771..2734241 + 471 WP_002892026.1 YlaC family protein -
I6K38_RS13600 2734216..2735667 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I6K38_RS13605 2735768..2736466 + 699 WP_004178762.1 GNAT family N-acetyltransferase -
I6K38_RS13610 2736463..2736603 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K38_RS13615 2736603..2736866 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192372 WP_002892050.1 NZ_CP069968:2732695-2732913 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T192372 NZ_CP092359:1647382-1647774 [Wielerella bovis]
ATGAAATATTTGCTGGATACCAATATTATCATCGCTTTTCAAAAACAACATCAAGGTTTATTGGCACAAATGAAAAAGCA
TTCGGTCAATGATTTTGCATTGTCCAACATTGTGTTATTTGAATTGGCATTTGGAGCATACAACAGCCAAAAGGTTGATG
AAAATTTACATAAATTAAGCCAATTACGCTTTCCCACCCTGACATTTAACAGCCAAGACGCTTATCACGCAGGCAAAATT
CGGGCAAACCTACAAAAACAAGGCACACCAATCGGTGCGTATGATACGCTGATTGCAGGTCAAGCCATTGCCCAAAATTT
GATTTTAATTAGCCATAATGTCAAAGAATTTGAACGGGTTGAAGGGTTAAAGTTTGAAAATTGGCTTGTGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT192372 WP_002892066.1 NZ_CP069968:2732294-2732668 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT192372 NZ_CP092359:1647143-1647385 [Wielerella bovis]
ATGACTACCGCAAAATTATTTTGGACAGGCAATTCCCAAGCCGTGCGATTGCCCAAAGAATTTCGTTTTGAAGGCAAAGA
AGTTCGTATTTCCAAACACGGCAATCAAGTGATTATTGAGCCGATTGCCGATGATTGGGGCTGGGTCAATGAGTTAGAAC
CTTTTGATAACACAATGGAACAAGCCATTTTGGAGCTAAAAAATGATGTGCCACAAGAGCGAGATTGGAGTGTTTTTGAA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References