Detailed information of TA system TA192370

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1301233..1302821
• Replicon: chromosome
• Accession: NZ_CP069968
• Organism: Klebsiella pneumoniae strain FDAARGOS_1308

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I6K38_RS06675
• Protein ID: WP_004179815.1
• Coordinates: 1301233..1302555 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6K38_RS06680
• Protein ID: WP_004176198.1
• Coordinates: 1302555..1302821 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K38_RS06660	1296289..1298790	+	2502	WP_004179823.1	fimbrial biogenesis outer membrane usher protein	-
I6K38_RS06665	1298778..1299782	+	1005	WP_004179822.1	type 1 fimbrial protein	-
I6K38_RS06670	1299924..1301216	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
I6K38_RS06675	1301233..1302555	-	1323	WP_004179815.1	type II toxin-antitoxin system HipA family toxin	Toxin
I6K38_RS06680	1302555..1302821	-	267	WP_004176198.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K38_RS06685	1303087..1303413	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
I6K38_RS06690	1303410..1303910	-	501	WP_004179811.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
I6K38_RS06695	1303888..1305267	-	1380	WP_004179808.1	purine permease	-
I6K38_RS06700	1305613..1306767	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
I6K38_RS06705	1306748..1307671	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49152.42 Da
• Isoelectric Point: 7.2850

>T192370 WP_004179815.1 NZ_CP069968:c1302555-1301233 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTHQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T192370 NZ_CP092359:773948-774349 [Wielerella bovis]
ATGTTACGCTATATGTTAGACACCAATATTTGCATTTACACGATTAAAAACAATCCTGCAATTGTGCGTGAAAAATTCCA
GCAACATCAACATCATTTATGTATTAGCAGTATTGTGTTAAGTGAATTATTGTATGGTGCGGAAAAATCGGACACGCCCA
CAAAATCATTGGCATTGATTGAAGGCTTGGCAGCGCGTTTGGAAGTGTTGGATTTTGATGAGAATGCGGCGGCGCATTCG
GCTGAAATTCGTGCGGAATTAGCCAAAAAAGGCACACCCATTGGGCATTATGATGTGCTGATTGCGGGACATGCGCGCAG
TCGTGGGCTGGTTTTGGTCAGCAATAATTTGCGTGAATTTGAGCGTGTGGGCGGGTTGCGGTTGGAGAATTGGTTATTAT
GA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9936.36 Da
• Isoelectric Point: 8.5912

>AT192370 WP_004176198.1 NZ_CP069968:c1302821-1302555 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMMLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT192370 NZ_CP092359:773721-773945 [Wielerella bovis]
ATGACGCAAGCGACTCTTTTTAAAAGCAATCAAACGCAAGCCGTGCGTTTACCCAAAGCCGTTGCCTTTCCCGATGGCGT
AAAAAAAGTAGAAGTGGTGGTTTTGGGTCAAACCCGTTTACTCACGCCCAGCGAAAACTTATGGGACGACTGGTTCGCGC
AATTACCACAAGTGGATTTCCCCGACCGTGAACCAACTTTTCAAGCCGAACGCGAAAGTTTTTAA