Detailed information of TA system TA192357

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 37241..37763
• Replicon: plasmid unnamed1
• Accession: NZ_CP069963
• Organism: Klebsiella pneumoniae strain FDAARGOS_1307

Toxin (Protein)

• Gene name: relE
• Uniprot ID: U9YLU1
• Locus tag: I6K37_RS26055
• Protein ID: WP_000638823.1
• Coordinates: 37241..37522 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: U9Y7J1
• Locus tag: I6K37_RS26060
• Protein ID: WP_000121741.1
• Coordinates: 37512..37763 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K37_RS26020	33390..33710	-	321	WP_000362080.1	VirB3 family type IV secretion system protein	-
I6K37_RS26025	33781..33969	-	189	WP_050567133.1	hypothetical protein	-
I6K37_RS26030	34071..34655	-	585	WP_001177113.1	lytic transglycosylase domain-containing protein	-
I6K37_RS26035	34676..35074	-	399	WP_001153665.1	hypothetical protein	-
I6K37_RS26040	35193..35630	-	438	WP_000539665.1	type IV pilus biogenesis protein PilM	-
I6K37_RS26045	35636..36871	-	1236	WP_015059538.1	TcpQ domain-containing protein	-
I6K37_RS26050	36874..37173	-	300	WP_000835764.1	IncN plasmid KikA protein	-
I6K37_RS26055	37241..37522	-	282	WP_000638823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I6K37_RS26060	37512..37763	-	252	WP_000121741.1	hypothetical protein	Antitoxin
I6K37_RS26065	37863..38498	-	636	WP_015059536.1	hypothetical protein	-
I6K37_RS26070	38546..39378	+	833	Protein_42	DNA primase	-
I6K37_RS26075	39415..39651	-	237	WP_000750964.1	EexN family lipoprotein	-
I6K37_RS26080	39655..40302	-	648	WP_000653673.1	conjugal transfer protein TrbJ	-
I6K37_RS26085	40308..41294	-	987	WP_001028544.1	type IV secretion system protein	-
I6K37_RS26090	41298..41555	-	258	WP_000739144.1	hypothetical protein	-
I6K37_RS26095	41552..41854	-	303	WP_001360345.1	hypothetical protein	-
I6K37_RS26100	42125..42571	-	447	WP_001243164.1	hypothetical protein	-
I6K37_RS26105	42582..42752	-	171	WP_000550720.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	blaCMY-2	-	1..64998	64998

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-87)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10945.79 Da
• Isoelectric Point: 10.4997

>T192357 WP_000638823.1 NZ_CP069963:c37522-37241 [Klebsiella pneumoniae]
MIYELAFDHRALKEWQKLGHTVREQFKKKLSERLINPRVPAAKLHGHTDRYKIKLRASGYRLVYQVIDEKVVLLVISVGK
REGSDVYHMADTR

Nucleotide

• Length: 282 bp

>T192357 NZ_CP092346:c592730-592344 [Rhizobium gallicum]
ATGGTGATCGATACCTCTGCGATTGTCGCGATCCTGCGCAGTGAACCAGAGGCCGCAACGCTCGAGAGAACGGTCGTCGC
CAACCCTATTCGTTTGGTCCCCGCGACATGTGTTCTTGAGACGCGTATGGTCTTGGTCAGCCGGCGCGGCGAACACGCAC
TTGCCGAGATCGATCTGTGGCTCGCCAGAATCGAGGCCGACATCGTTCCGGTCGACGCCGATCTGGTGGATCTGGCGACA
CAGGCCTGGCTTACTTACGGCAAGGGCCGCCATCCGGCGGCATTGAATTTTGCCGATTGTTTTTCCTACGCTTTGGCAAA
GCGTGCGGACGAACCGCTTCTCTTCATCGGCGAGGACTTTTCGCGCACCGATATCGAGGCGGCATAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9223.38 Da
• Isoelectric Point: 3.9823

>AT192357 WP_000121741.1 NZ_CP069963:c37763-37512 [Klebsiella pneumoniae]
MSYQILTTTAASITDLKKNPMGTVAEGEGDAVAILNRNEPAFYCVPPELYAYYRELAEDAELNAIADERMKNPDIVRVNL
DDL

Nucleotide

• Length: 252 bp

>AT192357 NZ_CP092346:c592987-592730 [Rhizobium gallicum]
ATGTCGCTCAATATCAAAAACCCCGCCACAGTCGCTCTCGTGGACGAGCTTGCGCGGCGGCAAGGTATCAGCAAGACCGC
AGCCATTCATCAGGCTTTGACGGAGCGTCTACATCGCATGGGATACGGCGATGTGGCGCAGGAGCGTCTGCTCACCGAGA
TGCAGGCGATCCGTGGGCGAGTGGCGCGATTGCCCGAACTCGACAGCCGAAGCGATGAAGAAATCATCGGCTACGATGAG
CATGGAATTCCGAACTGA

Structures

Toxin

• AlphaFold DB: U9YLU1

Antitoxin

• AlphaFold DB: U9Y7J1