Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
| Location | 5201656..5202242 | Replicon | chromosome |
| Accession | NZ_CP069962 | ||
| Organism | Klebsiella pneumoniae strain FDAARGOS_1307 | ||
Toxin (Protein)
| Gene name | doc | Uniprot ID | W8VD46 |
| Locus tag | I6K37_RS25105 | Protein ID | WP_002920800.1 |
| Coordinates | 5201874..5202242 (+) | Length | 123 a.a. |
Antitoxin (Protein)
| Gene name | phd | Uniprot ID | W9B1V1 |
| Locus tag | I6K37_RS25100 | Protein ID | WP_004174006.1 |
| Coordinates | 5201656..5201877 (+) | Length | 74 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K37_RS25080 | 5197813..5198739 | + | 927 | WP_002920807.1 | high-affinity branched-chain amino acid ABC transporter permease LivH | - |
| I6K37_RS25085 | 5198736..5200013 | + | 1278 | WP_004174005.1 | branched chain amino acid ABC transporter permease LivM | - |
| I6K37_RS25090 | 5200010..5200777 | + | 768 | WP_002920803.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG | - |
| I6K37_RS25095 | 5200779..5201492 | + | 714 | WP_004145133.1 | high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF | - |
| I6K37_RS25100 | 5201656..5201877 | + | 222 | WP_004174006.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| I6K37_RS25105 | 5201874..5202242 | + | 369 | WP_002920800.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
| I6K37_RS25110 | 5202515..5203831 | + | 1317 | WP_004174008.1 | sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB | - |
| I6K37_RS25115 | 5203938..5204825 | + | 888 | WP_002920792.1 | sn-glycerol-3-phosphate ABC transporter permease UgpA | - |
| I6K37_RS25120 | 5204822..5205667 | + | 846 | WP_004181473.1 | sn-glycerol-3-phosphate ABC transporter permease UgpE | - |
| I6K37_RS25125 | 5205669..5206739 | + | 1071 | WP_004150074.1 | sn-glycerol-3-phosphate import ATP-binding protein UgpC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 5196642..5207476 | 10834 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 123 a.a. Molecular weight: 13552.92 Da Isoelectric Point: 8.6410
>T192356 WP_002920800.1 NZ_CP069962:5201874-5202242 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG
Download Length: 369 bp
>T192356 NZ_CP092344:c3275952-3275362 [Rhizobium gallicum]
ATTTGGGGATGGGCTATTAAGAAGTCTAGTTACACAGTCATCCTTGATGCTTGCGTCTTGTATCCCGCGCCGCTGCGAGA
TTTCCTTATGGAACTCGCTGCGGCGGGGCAATTCAGAGCAAAGTGGTCAGATGAGATCCACGATGAATGGACACGAAACG
TACTGAAAAACCGTGACGACCTTACAATTGAGCAACTCGGTCGCACCAAGGATTTGATGAACGCAGCGGTGCCAGACAGT
GTGGTCGATGGCTATAGTGATCTTGTGCCTGCGCTTGCGCTTCCGGACCCAGACGATCGGCATTTCCTGGCAGCGGCGAT
AGTCTCAGCGAGCGACGCCATAGTCACGTTTAATCTCTCAGACTTTCCTAGGAAGACCGTTTCACAGTACGATATCGAAG
TCCTCCACCCGGACGATTTCATCCATCACCAATTTGGCCTGAACAATGCCGGCGTGATAATCGCCGCGCAACATTGTCGA
GCTCGTTTGAAAAACCCGCCTAAGACGGCATCCGAATATTTAGAAACACTAGAGCGTCAGGGGTTACCCAAGACCGTAGC
CGAACTGCGGGAATATCTTTTTGCGATTTAG
ATTTGGGGATGGGCTATTAAGAAGTCTAGTTACACAGTCATCCTTGATGCTTGCGTCTTGTATCCCGCGCCGCTGCGAGA
TTTCCTTATGGAACTCGCTGCGGCGGGGCAATTCAGAGCAAAGTGGTCAGATGAGATCCACGATGAATGGACACGAAACG
TACTGAAAAACCGTGACGACCTTACAATTGAGCAACTCGGTCGCACCAAGGATTTGATGAACGCAGCGGTGCCAGACAGT
GTGGTCGATGGCTATAGTGATCTTGTGCCTGCGCTTGCGCTTCCGGACCCAGACGATCGGCATTTCCTGGCAGCGGCGAT
AGTCTCAGCGAGCGACGCCATAGTCACGTTTAATCTCTCAGACTTTCCTAGGAAGACCGTTTCACAGTACGATATCGAAG
TCCTCCACCCGGACGATTTCATCCATCACCAATTTGGCCTGAACAATGCCGGCGTGATAATCGCCGCGCAACATTGTCGA
GCTCGTTTGAAAAACCCGCCTAAGACGGCATCCGAATATTTAGAAACACTAGAGCGTCAGGGGTTACCCAAGACCGTAGC
CGAACTGCGGGAATATCTTTTTGCGATTTAG
Antitoxin
Download Length: 74 a.a. Molecular weight: 8151.15 Da Isoelectric Point: 4.7769
>AT192356 WP_004174006.1 NZ_CP069962:5201656-5201877 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK
Download Length: 222 bp
>AT192356 NZ_CP092344:c3276379-3275933 [Rhizobium gallicum]
ATGTCGCAACTGCTAGAACGCCCAATCCTGCCGTCGGCGGACGATACAGAATTGGCCGCCGAGGCCAGTCGCTACATTTC
ACGTGCGAAGCATGAAGGTGCTGAACTTCGAGTTCAAGTTGATGGCGGGGAGCTTCTAAAGCTTCCCAAGGCTGTCAGCG
AGTTGCTGTATCATCTCCTAACTGAAATGGCTCAGGGTAATGCTGTAACTTTGATACCCGTCCATGCTGAGCTGACAACT
CAGGAGGCGGCAGATCATCTTAATGTGTCGCGGCCCTACCTGATCAAACTTTTGGAAGAGGGGAAAATCCCATTCCATAT
GGTTGGAAGCCATCGCCGAATAAAGTTTAGCGACCTGGACGGTTTCCGTCGAAAGGCTGAGGACGAAAGAAAACGGCTCA
TGGACGAGCTGGCGAGCCAGGCCCAAGATTTGGGGATGGGCTATTAA
ATGTCGCAACTGCTAGAACGCCCAATCCTGCCGTCGGCGGACGATACAGAATTGGCCGCCGAGGCCAGTCGCTACATTTC
ACGTGCGAAGCATGAAGGTGCTGAACTTCGAGTTCAAGTTGATGGCGGGGAGCTTCTAAAGCTTCCCAAGGCTGTCAGCG
AGTTGCTGTATCATCTCCTAACTGAAATGGCTCAGGGTAATGCTGTAACTTTGATACCCGTCCATGCTGAGCTGACAACT
CAGGAGGCGGCAGATCATCTTAATGTGTCGCGGCCCTACCTGATCAAACTTTTGGAAGAGGGGAAAATCCCATTCCATAT
GGTTGGAAGCCATCGCCGAATAAAGTTTAGCGACCTGGACGGTTTCCGTCGAAAGGCTGAGGACGAAAGAAAACGGCTCA
TGGACGAGCTGGCGAGCCAGGCCCAAGATTTGGGGATGGGCTATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GUD1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5E5YJY7 |