Detailed information of TA system TA192354

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4487268..4488949
• Replicon: chromosome
• Accession: NZ_CP069962
• Organism: Klebsiella pneumoniae strain FDAARGOS_1307

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: I6K37_RS21800
• Protein ID: WP_004178299.1
• Coordinates: 4487268..4488185 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: I6K37_RS21805
• Protein ID: WP_004177809.1
• Coordinates: 4488191..4488949 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K37_RS21780	4482574..4484094	+	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-
I6K37_RS21785	4484091..4485089	+	999	WP_002885172.1	ribose ABC transporter permease	-
I6K37_RS21790	4485120..4486061	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K37_RS21795	4486136..4487143	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
I6K37_RS21800	4487268..4488185	-	918	WP_004178299.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K37_RS21805	4488191..4488949	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6K37_RS21810	4489035..4489763	-	729	WP_004178298.1	response regulator transcription factor	-
I6K37_RS21815	4490036..4492183	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6K37_RS21820	4492413..4493099	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34649.06 Da
• Isoelectric Point: 5.4707

>T192354 WP_004178299.1 NZ_CP069962:c4488185-4487268 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPSQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T192354 NZ_CP092344:283547-283843 [Rhizobium gallicum]
ATGATCGTCGGTTTCCGGGACGAATGGTTGCGGGCCTACTTTGTGGAGGATGTCCACTCCCGGAACATTCCAGCCGACCT
CGAAAGCCGGTTGTTCCGCAAACTCCAAATGATCGACGACGCGACGACCGATCAGGACTTGCGTGTGCCGCCCAGTAACC
ATTTCGAGAAACTACGCGGCAATCTCGAGGGTTTGCATTCAATCCGCGTCAACCGGCAATGGCGGGTTGTCTTTCGATGG
GATGGCAGTCGTGGCGAGGCGTCCGAGGTCTATCTTGACGACCATAGCTATCGATGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT192354 WP_004177809.1 NZ_CP069962:c4488949-4488191 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT192354 NZ_CP092344:283852-284160 [Rhizobium gallicum]
ATGCTGATGACCAAGCGTAAGCCGGCGACGGTCGGCGAAATCCTGAGGGAAGAATTCATGCAGCCGCTCGACCTGACGCA
GGCGGTCTTGGCCGAGGCAATGGGCGTCCAGCGCAAGCATGTGAATGAATTGTGCAACGACCGGCGTAACGTGACGGCGG
CAACCGCGCTGATCCTGGCGCGCGTGTTTGGTAACAGCCCGGACTTCTGGCTCAACGTGCAGCGGCGCAGCGACTTATGG
GATGCCATGCATAGCCCCAAGGAACTGGCGCGGATCGAGCGCGCGAAGCCGCTAGCGACAGCGGCATAG

Structures

Antitoxin

• AlphaFold DB: A6TH05