Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4331573..4332089 Replicon chromosome
Accession NZ_CP069962
Organism Klebsiella pneumoniae strain FDAARGOS_1307

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag I6K37_RS21005 Protein ID WP_004178374.1
Coordinates 4331573..4331857 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K37_RS21010 Protein ID WP_002886901.1
Coordinates 4331847..4332089 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K37_RS20980 4327057..4327365 - 309 WP_004178377.1 PTS sugar transporter subunit IIB -
I6K37_RS20985 4327450..4327623 + 174 WP_032408826.1 hypothetical protein -
I6K37_RS20990 4327626..4328369 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K37_RS20995 4328726..4330864 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K37_RS21000 4331105..4331569 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K37_RS21005 4331573..4331857 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K37_RS21010 4331847..4332089 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K37_RS21015 4332167..4334077 - 1911 WP_004178373.1 BglG family transcription antiterminator -
I6K37_RS21020 4334100..4335254 - 1155 WP_004178372.1 lactonase family protein -
I6K37_RS21025 4335321..4336061 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T192353 WP_004178374.1 NZ_CP069962:c4331857-4331573 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T192353 NZ_CP092337:86378-86683 [Klebsiella pneumoniae]
ATGCAGTTTAAGGTTTATGCCTATAAAAGAGAGAGCCGCTATCGTCTGTTCGTGGATGTGCAGAGTGACATCATCGATAC
CCCCGGGCGACGGATGGTGATCCCGCTGGCCAGCGCCCGGCTGCTGTCGGATAAGGTTTCCCGTGAACTCTATCCGGTGG
TGCACATCGGGGATGAAAGCTACCGCCTGATGACCACGGACATGGCCAGCGTCACGTCCTCCGTCACCGGGGAGGAAGTG
GCCGATCTCAGCCACCGGGAAAATGACATCAAAAATGCGATAAACCTGATGTTCTGGGGAATTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT192353 WP_002886901.1 NZ_CP069962:c4332089-4331847 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192353 NZ_CP092337:86158-86376 [Klebsiella pneumoniae]
ATGAAGCAGCGCATCACCGTCACCATAGACAGCGACAGTTATCAGTTACTGAAATCCGCGGACGTCAATATCTCCGGCCT
GGTGAACAGGGCCATGCAGAATGAGGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCCGAAAATCAGGAAGGGATGGCCG
AGGTTGCCCGCTTTATTGAGATGAACGGTTCATTCGCCGACGAAAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References