Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3626409..3627028 Replicon chromosome
Accession NZ_CP069962
Organism Klebsiella pneumoniae strain FDAARGOS_1307

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K37_RS17740 Protein ID WP_002892050.1
Coordinates 3626810..3627028 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K37_RS17735 Protein ID WP_002892066.1
Coordinates 3626409..3626783 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K37_RS17725 3621561..3622754 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
I6K37_RS17730 3622777..3625923 + 3147 WP_204745926.1 multidrug efflux RND transporter permease subunit AcrB -
I6K37_RS17735 3626409..3626783 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K37_RS17740 3626810..3627028 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K37_RS17745 3627187..3627753 + 567 WP_002892030.1 maltose O-acetyltransferase -
I6K37_RS17750 3627725..3627865 - 141 WP_004147370.1 hypothetical protein -
I6K37_RS17755 3627886..3628356 + 471 WP_002892026.1 YlaC family protein -
I6K37_RS17760 3628331..3629782 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
I6K37_RS17765 3629883..3630581 + 699 WP_004178762.1 GNAT family N-acetyltransferase -
I6K37_RS17770 3630578..3630718 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K37_RS17775 3630718..3630981 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192351 WP_002892050.1 NZ_CP069962:3626810-3627028 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T192351 NZ_CP092337:22455-22871 [Klebsiella pneumoniae]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGCCACGCCATCGCGGCCGGCGCCATCCTGGTGACGAATAATACAAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT192351 WP_002892066.1 NZ_CP069962:3626409-3626783 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT192351 NZ_CP092337:22228-22458 [Klebsiella pneumoniae]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGAGCTCGTTCGCGCAGCTGG
ACAGGGCCGATCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References