Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4847606..4849194 Replicon chromosome
Accession NZ_CP069961
Organism Klebsiella pneumoniae strain FDAARGOS_1317

Toxin (Protein)


Gene name hipA Uniprot ID W9B834
Locus tag I6K47_RS23635 Protein ID WP_016529318.1
Coordinates 4847606..4848928 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A483IVM3
Locus tag I6K47_RS23640 Protein ID WP_029496892.1
Coordinates 4848928..4849194 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K47_RS23620 4842662..4845163 + 2502 WP_204779790.1 fimbria/pilus outer membrane usher protein -
I6K47_RS23625 4845151..4846155 + 1005 WP_009485243.1 type 1 fimbrial protein -
I6K47_RS23630 4846297..4847589 + 1293 WP_110138968.1 glycoside hydrolase family 10 protein -
I6K47_RS23635 4847606..4848928 - 1323 WP_016529318.1 type II toxin-antitoxin system HipA family toxin Toxin
I6K47_RS23640 4848928..4849194 - 267 WP_029496892.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
I6K47_RS23645 4849581..4849907 - 327 WP_002904788.1 hydroxyisourate hydrolase -
I6K47_RS23650 4849904..4850404 - 501 WP_020804988.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
I6K47_RS23655 4850382..4851761 - 1380 WP_020804975.1 purine permease -
I6K47_RS23660 4852107..4853261 + 1155 WP_020804972.1 FAD-dependent urate hydroxylase HpxO -
I6K47_RS23665 4853242..4854165 - 924 WP_002904781.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-64)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49125.44 Da        Isoelectric Point: 7.5366

>T192339 WP_016529318.1 NZ_CP069961:c4848928-4847606 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T192339 NZ_CP092334:c2047356-2047024 [Flavihumibacter rivuli]
GTGCGAAAAGCCGCCATAAAAATAGACAACCAACTAGCCGGATGGCTCACCCAGGATGAGCAGGGGTATCATTTTGTATA
CGACCAGGCGTATGCAGCACAACCCGGTGCCCGGCCAGTCAGTTTGACCCTTCCGCTACAAGAAGCTCCTTATACTTCAA
AAGTGCTTTTTCCTTTTTTTGATGGCCTGATACCCGAAGGGTGGTTGTTGGATATAGCAGAAAAAAACTGGAAACTGAAT
CCAAGGGACCGGATGGGATTATTGCTGGCCTGCTGTAAAGATTGCATTGGAATAGTAAGTGTGGAAGCAATAAAAGAGGA
GGAGGCACCATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9938.33 Da        Isoelectric Point: 8.5912

>AT192339 WP_029496892.1 NZ_CP069961:c4849194-4848928 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGMVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT192339 NZ_CP092334:c2047605-2047396 [Flavihumibacter rivuli]
ATGAACCTGGCAGACTTTGTAAAAGACAAGCGGAAATCGGTGAAGCTCACCCAGCCCGAACTGGCCGAAAAGGCGGGTGT
AGGGCTGCGTTTCATCCGTGAACTGGAACAGGGAAAGGAAACCCTACGGTTGGATAAAGTGAACCAGGTGCTGCAACTCT
TCGGTTACGAAGTAGGTGCCGTACCCAAAACCACCAACCCCTATACCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W9B834

Antitoxin

Source ID Structure
AlphaFold DB A0A483IVM3

References