Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3095273..3095930 Replicon chromosome
Accession NZ_CP069961
Organism Klebsiella pneumoniae strain FDAARGOS_1317

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K47_RS15075 Protein ID WP_002916310.1
Coordinates 3095520..3095930 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K47_RS15070 Protein ID WP_002916312.1
Coordinates 3095273..3095539 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K47_RS15045 3090429..3091862 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I6K47_RS15050 3091981..3092709 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K47_RS15055 3092759..3093070 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K47_RS15060 3093234..3093893 + 660 WP_002916317.1 hemolysin III family protein -
I6K47_RS15065 3094044..3095027 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I6K47_RS15070 3095273..3095539 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K47_RS15075 3095520..3095930 + 411 WP_002916310.1 protein YgfX Toxin
I6K47_RS15080 3095937..3096458 - 522 WP_002916308.1 flavodoxin FldB -
I6K47_RS15085 3096559..3097455 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K47_RS15090 3097478..3098191 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K47_RS15095 3098197..3099930 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192329 WP_002916310.1 NZ_CP069961:3095520-3095930 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192329 NZ_CP092289:c2821636-2821241 [Marinobacter sp. M1C]
GTGATACGTATTTTCAAGTCAGTCACGATCCAAAAACTGTTCAAAGAACAGGATTTAGACGATCTCATCAACGACTTTCG
AAAGTACAAGGAAAGTGGTCTTTGCCCGGATTACTTTGGGCGGGATGTCGCCTATGATCACCCGCATACTCCATCGCTAA
TTCTGCAGGAAGATGTGCGTCACGTTCATTTATCAGAATTCGGCGCCTGGCCGGTTCGGCTAATGCAATTTAATCGCACG
AGTGATCGGCACCTGGTTTATTGTCAAGGTGCCATCCACAGGGAGTGTTACCTGCTCATCACACTTCTGAGCCCTGATGC
CCATGAGCAAGCCACCGTTAGCAACGTCATGCGCAAAATTGGAGAGCAAGCTGAAATTTTTCGAATGAAGTATTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192329 WP_002916312.1 NZ_CP069961:3095273-3095539 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192329 NZ_CP092289:c2821932-2821633 [Marinobacter sp. M1C]
ATGGCAACAAATGCTATCTTAGCGGAAAAGTCGGTCAGTATTTCTGCACTACGCAATAATCCGGCGCAGTATTTCCAAAA
CGAGCCTATTGCGGTTTTGAACCACAACAAGCCAGCAGGCTACATGATTGGTGCAGAGCTGTTTGAGAAGATGGTTCAGT
TGATTGGGGATCAGGAAGAATCGCGTACGTTTGTGGGACGTTTTCGTCCGCGAGGCTCTGAGCTTGCTGACCTCTGTAAA
AAGGGAGCTGACTTAATGCTGGAAACGACCCGAGAGGACATGGAGGGCTTCTCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References