Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2611468..2612054 Replicon chromosome
Accession NZ_CP069961
Organism Klebsiella pneumoniae strain FDAARGOS_1317

Toxin (Protein)


Gene name doc Uniprot ID A0A486RB10
Locus tag I6K47_RS12565 Protein ID WP_004174007.1
Coordinates 2611686..2612054 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag I6K47_RS12560 Protein ID WP_004174006.1
Coordinates 2611468..2611689 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K47_RS12540 2607625..2608551 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
I6K47_RS12545 2608548..2609825 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
I6K47_RS12550 2609822..2610589 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
I6K47_RS12555 2610591..2611304 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
I6K47_RS12560 2611468..2611689 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I6K47_RS12565 2611686..2612054 + 369 WP_004174007.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I6K47_RS12570 2612327..2613643 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
I6K47_RS12575 2613750..2614637 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
I6K47_RS12580 2614634..2615479 + 846 WP_004174009.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
I6K47_RS12585 2615481..2616551 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2606454..2617288 10834


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(6-116)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13568.97 Da        Isoelectric Point: 8.6410

>T192327 WP_004174007.1 NZ_CP069961:2611686-2612054 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDLGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T192327 NZ_CP092289:c1912721-1912455 [Marinobacter sp. M1C]
ATGATTAGATCATTCCGTCACAAAGGTCTGAAACGGTTCTACTCGTCTGGCATACAGTCTGATCACGCCAAGAAGCTGCG
CATGCAGCTCGCTGCTCTGAATACCGCCATTTCGGTAGAAGACATAGACATCCCTGGTTTTCGGCTTCACTCATTGAAGG
GAACAGACAAAGGGCGGTGGTCGATTTGGGTTAACGGAAATTGGCGCATGACGTTCGAATTTCAGGACAGCAACGCCTAC
ATTCTTGATTATGAGGATTACCACTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT192327 WP_004174006.1 NZ_CP069961:2611468-2611689 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT192327 NZ_CP092289:c1912455-1912162 [Marinobacter sp. M1C]
ATGACTATGCATAACCCGCCACATCCTGGTGAGTTCATTCGGGAGGTGTATCTGGAGCCTTTCGGCATCAGTTCCCGTCA
GCTTGCTTCCAGTTTGGGCGTTTCCCCTTCTACGTTGTCTCGCTTGCTCAAAGGGGATAGTGGTATCAGCCCGGAGATGT
CTTTGCGGCTATCTAAGGTTCTCGGGCGTACTCCTGAGAGCTGGTTGGCTATGCAAGATATGTATGATCTATGGGTAGCC
CGTAGCACGGTCAATCTGGATGGTATTCATCCCTTGGACTTCGAAGCAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486RB10

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References