Detailed information of TA system TA192325

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1884089..1885770
• Replicon: chromosome
• Accession: NZ_CP069961
• Organism: Klebsiella pneumoniae strain FDAARGOS_1317

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: J2XCI1
• Locus tag: I6K47_RS09185
• Protein ID: WP_004146663.1
• Coordinates: 1884089..1885006 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: I6K47_RS09190
• Protein ID: WP_004177809.1
• Coordinates: 1885012..1885770 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K47_RS09165	1879395..1880915	+	1521	WP_204779856.1	ATP-binding cassette domain-containing protein	-
I6K47_RS09170	1880912..1881910	+	999	WP_002885172.1	ribose ABC transporter permease	-
I6K47_RS09175	1881941..1882882	+	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K47_RS09180	1882957..1883964	+	1008	WP_004177805.1	carbohydrate kinase family protein	-
I6K47_RS09185	1884089..1885006	-	918	WP_004146663.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K47_RS09190	1885012..1885770	-	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6K47_RS09195	1885856..1886584	-	729	WP_004177810.1	response regulator transcription factor	-
I6K47_RS09200	1886857..1889004	+	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6K47_RS09205	1889350..1890036	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34659.10 Da
• Isoelectric Point: 5.4707

>T192325 WP_004146663.1 NZ_CP069961:c1885006-1884089 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T192325 NZ_CP092289:c1049996-1049742 [Marinobacter sp. M1C]
CTGGAACGATGCCGCAAATTCTTAGCCGCCAAAGCCCCGGAAGCCAGTAGGCGGGCAGGACAAACCATCGAACGGCACTT
CCTGTTTTTGGAAACAGCCACGGGTATTGGCCGGCCGTTCGCTGAAATGCCTGAATTGCGCGAATTAGTTATTGCCTTCG
GGAACTCCGGGTATGTGGCCCTGTACCACCATGAACCGGCCGACGATGCAGTATATGTTCTGGCCTTCCGGCACCAAAAA
GAAGCGGGCTTTTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT192325 WP_004177809.1 NZ_CP069961:c1885770-1885012 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT192325 NZ_CP092289:c1050295-1050023 [Marinobacter sp. M1C]
ATGGCAACATCTCTCAAAATCGACAACACACTAAAAAGCCGCGTTCATCACATCGCCAACCAACGCCGCCGCTCTCCGCA
CTGGATCATGCTGGAAGCCATACAGCAGTACGTTGAGCGCGAGGAAGCACGCGAGAGTTTCAAGCAGGAGGCCTTAGCGT
CTTGGTCAGCCTACAAGGAAACCGGCAGACACCTGACCGGCCAAGAAGCTCGCGCCTGGTTGAATACTTGGGGCAACGAT
GATGAGAAGGCGGCGCCAGAGTGCCACGAGTAA

Structures

Toxin

• AlphaFold DB: J2XCI1

Antitoxin

• AlphaFold DB: A6TH05