Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1728500..1729016 Replicon chromosome
Accession NZ_CP069961
Organism Klebsiella pneumoniae strain FDAARGOS_1317

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag I6K47_RS08395 Protein ID WP_009486548.1
Coordinates 1728500..1728784 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K47_RS08400 Protein ID WP_002886901.1
Coordinates 1728774..1729016 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K47_RS08370 1723896..1724204 - 309 WP_002886907.1 PTS sugar transporter subunit IIB -
I6K47_RS08375 1724289..1724462 + 174 WP_004222159.1 hypothetical protein -
I6K47_RS08380 1724465..1725208 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K47_RS08385 1725565..1727703 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K47_RS08390 1728032..1728496 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K47_RS08395 1728500..1728784 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K47_RS08400 1728774..1729016 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K47_RS08405 1729094..1731004 - 1911 WP_204779854.1 PRD domain-containing protein -
I6K47_RS08410 1731027..1732181 - 1155 WP_004178372.1 lactonase family protein -
I6K47_RS08415 1732248..1732988 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T192324 WP_009486548.1 NZ_CP069961:c1728784-1728500 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T192324 NZ_CP092289:c1049325-1049035 [Marinobacter sp. M1C]
ATGAGCTCTAAGTACGCTCTAGAATTCAAACCCTCTGCCCTTAAAGAATGGAAGAAGCTCGCACCGGCGCTGCAGGCTCA
GTTTAAGAAAAAGCTCAAACAGCGGCTCGACGATCCTCACGTGCCGCCAGACGCCCTATCCGATCTCAAGAACTGCTACA
AAATCAAACTTCGCAGCGCAGGTTACCGATTGGTTTATGAGGTCGAAAACGAGCGCATCGTTGTAACGGTGGTCGCCGTG
GGCAAGCGAGAGCGTGGTGCGGTGTACAGTCGGGCTCACCGACGAATCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT192324 WP_002886901.1 NZ_CP069961:c1729016-1728774 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192324 NZ_CP092289:c1049563-1049315 [Marinobacter sp. M1C]
ATGACTCAACCCATTTATACCGAAATTGCGGCTAGTATCTCGGAGTTAAAGAAAAACCCAATGGCAGCTGTTAGTGCCGG
CGAGGGGTTTCCCATCGTTGTTTTGAACCGAAATAAACCAGCATTCTACTGCGTGCCAGCGGATGTTTACGAGGCTATGC
TGGATCGCCTGGACGATCAAGAATTGGCTCGCCTGGTGGAGTCGCGCCGATCAGAACGCAGCATCCCGGTGTCCCTGAAT
GAGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References