Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4157922..4158754 Replicon chromosome
Accession NZ_CP069957
Organism Escherichia coli strain FDAARGOS_1279

Toxin (Protein)


Gene name yeeV Uniprot ID A0A3P5UBZ5
Locus tag I6K09_RS19890 Protein ID WP_001094454.1
Coordinates 4157922..4158296 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3G8RJV8
Locus tag I6K09_RS19895 Protein ID WP_001320394.1
Coordinates 4158386..4158754 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K09_RS19860 (4153035) 4153035..4154183 - 1149 WP_000905922.1 capsule polysaccharide export inner-membrane protein KpsE -
I6K09_RS19865 (4154255) 4154255..4155238 - 984 WP_001298261.1 KpsF/GutQ family sugar-phosphate isomerase -
I6K09_RS19870 (4156049) 4156049..4156219 - 171 Protein_3916 IS110 family transposase -
I6K09_RS19875 (4156562) 4156562..4157131 - 570 WP_001290250.1 DUF4942 domain-containing protein -
I6K09_RS19880 (4157228) 4157228..4157425 - 198 WP_000839276.1 DUF957 domain-containing protein -
I6K09_RS19885 (4157437) 4157437..4157925 - 489 WP_000777545.1 DUF5983 family protein -
I6K09_RS19890 (4157922) 4157922..4158296 - 375 WP_001094454.1 TA system toxin CbtA family protein Toxin
I6K09_RS19895 (4158386) 4158386..4158754 - 369 WP_001320394.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6K09_RS19900 (4158804) 4158804..4159447 - 644 Protein_3922 antitoxin of toxin-antitoxin stability system -
I6K09_RS19905 (4159466) 4159466..4159687 - 222 WP_000692300.1 DUF987 domain-containing protein -
I6K09_RS19910 (4159750) 4159750..4160226 - 477 WP_001347688.1 RadC family protein -
I6K09_RS19915 (4160242) 4160242..4160727 - 486 WP_029701480.1 antirestriction protein -
I6K09_RS19920 (4160782) 4160782..4161600 - 819 WP_001234642.1 DUF932 domain-containing protein -
I6K09_RS19925 (4161700) 4161700..4161933 - 234 WP_001119719.1 DUF905 family protein -
I6K09_RS19930 (4162012) 4162012..4162467 - 456 WP_000581493.1 IrmA family protein -
I6K09_RS19935 (4162544) 4162544..4163407 - 864 Protein_3929 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 14059.10 Da        Isoelectric Point: 9.2447

>T192305 WP_001094454.1 NZ_CP069957:c4158296-4157922 [Escherichia coli]
MNTLPDTHVRKASRCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCPRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEKR

Download         Length: 375 bp

>T192305 NZ_CP092288:c1051006-1050716 [Marinobacter sp. M2C]
ATGAGCTCTAAGTACGCTCTAGAATTCAAACCCTCTGCCCTTAAAGAATGGAAGAAGCTCGCACCGGCGCTGCAGGCTCA
GTTTAAGAAAAAGCTCAAACAGCGGCTCGACGATCCTCACGTGCCGCCAGACGCCCTATCCGATCTCAAGAACTGCTACA
AAATCAAACTTCGCAGCGCAGGTTACCGATTGGTTTATGAGGTCGAAAACGAGCGCATCGTTGTAACGGTGGTCGCCGTG
GGCAAGCGAGAGCGTGGTGCGGTGTACAGTCGGGCTCACCGACGAATCTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13623.22 Da        Isoelectric Point: 6.4783

>AT192305 WP_001320394.1 NZ_CP069957:c4158754-4158386 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPSTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADANHLDQAFPLLMKQLELMFTSS
ELNPHRQNTVTLYAKGLTCHADTLGSCGYVYLAVYPTPETKQ

Download         Length: 369 bp

>AT192305 NZ_CP092288:c1051244-1050996 [Marinobacter sp. M2C]
ATGACTCAACCCATTTATACCGAAATTGCGGCTAGTATCTCGGAGTTAAAGAAAAACCCAATGGCAGCTGTTAGTGCCGG
CGAGGGGTTTCCCATCGTTGTTTTGAACCGAAATAAACCAGCATTCTACTGCGTGCCAGCGGATGTTTACGAGGCTATGC
TGGATCGCCTGGACGATCAAGAATTGGCTCGCCTGGTGGAGTCGCGCCGATCAGAACGCAGCATCCCGGTGTCCCTGAAT
GAGCTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3P5UBZ5

Antitoxin

Source ID Structure
AlphaFold DB A0A3G8RJV8

References