Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 2681802..2682397 Replicon chromosome
Accession NZ_CP069957
Organism Escherichia coli strain FDAARGOS_1279

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag I6K09_RS12920 Protein ID WP_000239581.1
Coordinates 2681802..2682152 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag I6K09_RS12925 Protein ID WP_001223213.1
Coordinates 2682146..2682397 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K09_RS12900 (2677256) 2677256..2678278 - 1023 WP_001361374.1 ABC transporter permease -
I6K09_RS12905 (2678292) 2678292..2679794 - 1503 WP_001522399.1 sugar ABC transporter ATP-binding protein -
I6K09_RS12910 (2679927) 2679927..2680883 - 957 WP_001522398.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
I6K09_RS12915 (2681193) 2681193..2681723 + 531 WP_000055075.1 inorganic diphosphatase -
I6K09_RS12920 (2681802) 2681802..2682152 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
I6K09_RS12925 (2682146) 2682146..2682397 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
I6K09_RS12930 (2682609) 2682609..2682950 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
I6K09_RS12935 (2682953) 2682953..2686732 - 3780 WP_001522396.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T192299 WP_000239581.1 NZ_CP069957:c2682152-2681802 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T192299 NZ_CP092284:4454565-4455878 [Marinobacter sp. M3C]
GTGAGCACCGTTACGGAAGTTATCCTATGGGGGAAGAGTGTCGGTGCCCTGCTGTATGACACAGAAACCGGTCTGTCGAC
ATTCGAATACGATAAGGGTTGGTTGAAGCAGGACGTTTCAATTTCCCCGCTCCACCTACCTCCTCGGGCTGGGAGGTTCA
ATTTCCCCTCATTGCCACAGGAAACGTTCTTTGGACTGCCGGGCGTGTTTGCCGACACTTTGCCAGATGACTTTGGCAAT
GCCGTTATCAACGCCTGGCTGGCTCGCCAGGGAATCCCAAAAAGCTCATTCAGCCCGGTTGACCGCCTCCTATACACCGG
CAACCGTGGCATGGGTGCGCTGGAGTACAAGCCAGACGGCCGAAACACTCAGACTCAGGTATCAGGAGATATCAAGGTCG
ATACACTGGTCGAGTTGGCTCAGTCCGTGTTGGACCAAAGAGCTGGCCTGGATGTGGCCATATCAGAGGGTGATGAGAAC
AATGATGCGATGAGTGCCATTTTCCAGGTGGGCACATCGGCGGGTGGGGCTCGTCCCAAGGCCGTTATTGCCGTGAACCG
TGATCGTTCTCGGGTAGTTTCCGGCCAGACTCCCATACCCGAAGGATTCACTCACTACCTCATTAAATTCGATGGGGTCA
AAGAGCGATCATCCACCAGCGAGGTCTTTGGTGACCCGCAGGGGTATGGCCGGATGGAATATGCCTACTACCTGATGGCC
AAAGACGCAGGCATCAATATGGCACCGTCTGAACTGTTGATAGAAGGGGCGCGAGCCCATTTTATGACACAGCGTTTCGA
CCGGGACGGTGACCGCAAGCGCCACTACCAGTCCCTATGCGCGATGGACCATGCGGACTTCCGGAAACCTGGCCAGTACA
GCTATGAAGAACTGATGACCATTGCCCGAACACTCGGGTTGCCACGGGTAGACGCAATCGAGATTTTCAGGCGTATGGTC
TTCAACGTCATTGCCCGGAACCAGGACGACCATACCAAGAACTTTGGCTTTCTGTTGGATCATTCAACGGCCGGTTGGCG
TTTGGCACCGGCGTTTGATATCGCCTACAGCTACAAACCCGGTTCATACTGGGTGGACACCCATCAGATGACCATCAACG
GTAAACGGGATAAGTTCACTCGCGGGGATATTCTCGCAGTCGCAACCCAAATTCCCCGTTTCGAGTCAAATGCCCGGGCC
ATTATTGACCAGGTAACTGAGGTGGTGAACCAATGGCAGGATTATGCTCGCCGAGCGGATGTCCATTCGGAGCTGTCACA
GGAGATTTACTCCAACCTCCGGTTGTCCTTGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT192299 WP_001223213.1 NZ_CP069957:c2682397-2682146 [Escherichia coli]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT192299 NZ_CP092284:4454227-4454568 [Marinobacter sp. M3C]
ATGAGCCAAATTAAGCGCAGCATGTCAGACTTGGCCATCCTCGATGAGCTGGGTCGGCGCCTCAAGCAAGCCCGACTGGA
GCAAAACATCACCCAGCAGCAGATCGCAGAGGGTATGGGGGTCAGCCGAGCAACGTACATCCGGCTTGAGGATGGTAACG
GGAAACTTGAAGTCCTGGTTGCTGCCCTGCGTGTTCTCGGAAAGCTCCCGGCGTTGGATGCCTTCTTGCCAGATGAGCCT
TATTCACCGATTGCGGCATTAAAGAGTGCTGGCCATATTCGCCAGCGTGCACGCCCCGGTAATAAGCCCGTTGAACAGGA
CAAAGGAGGCCTGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References