Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2670261..2670783 Replicon chromosome
Accession NZ_CP069957
Organism Escherichia coli strain FDAARGOS_1279

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag I6K09_RS12860 Protein ID WP_001105433.1
Coordinates 2670261..2670551 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I6K09_RS12865 Protein ID WP_000212715.1
Coordinates 2670541..2670783 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K09_RS12845 (2665424) 2665424..2667079 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
I6K09_RS12850 (2667473) 2667473..2669611 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
I6K09_RS12855 (2669796) 2669796..2670260 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K09_RS12860 (2670261) 2670261..2670551 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K09_RS12865 (2670541) 2670541..2670783 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K09_RS12870 (2670975) 2670975..2671361 - 387 WP_001232246.1 cytochrome b562 -
I6K09_RS12875 (2671545) 2671545..2672897 - 1353 WP_001162173.1 metalloprotease PmbA -
I6K09_RS12880 (2672991) 2672991..2673542 + 552 WP_000166270.1 ribosome biogenesis factor YjgA -
I6K09_RS12885 (2673694) 2673694..2675067 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T192298 WP_001105433.1 NZ_CP069957:c2670551-2670261 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T192298 NZ_CP092284:2641568-2641822 [Marinobacter sp. M3C]
ATGAAACTTATCTTCTCCGAGAACGCCTGGGAAGACTATCTGTATTGGCAGAAAACTGACAAAAAAGCCCTTAACCGAAT
CAACAAGCTGATCAAGGAGACTAAGCGAGAACCGTTCGAAGGTGTCGGTAAGCCGGAGCCCCTCAAACACAACCTCGCTG
GTTACTGGTCCCGCCGAATTAACGAAGAGCACCGCATCGTTTACAAAGTCACGGATGACGCTTTACTCATAGCCCAACTC
CGTTACCACTACTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT192298 WP_000212715.1 NZ_CP069957:c2670783-2670541 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT192298 NZ_CP092284:2641320-2641571 [Marinobacter sp. M3C]
ATGGATGCCATCAGCTACACAGCCGCTAGAACTAACCTAGCAAAAACCATGGAGCAGGTCTGTGAAGACCATTCTCCTGT
GATCATCACCCGGAGCAAGTCACAATCCGTGGTGATGATTTCTCTTGAGGACTATGAGGCGCTGCAAGAGACTGCATACT
TGCTGCGCGCACCAAAAAATGCCCGTCGTTTGCTGGAATCCGTTGCCGAGCTCGAGCAAGGCGGTGGTCAAGAAAAGGAA
CTTCTTGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References