Detailed information of TA system TA192290

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 687313..688274
• Replicon: chromosome
• Accession: NZ_CP069957
• Organism: Escherichia coli strain FDAARGOS_1279

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A1Q5ZNB7
• Locus tag: I6K09_RS03440
• Protein ID: WP_021523084.1
• Coordinates: 687579..688274 (+)
• Length: 232 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I6K09_RS03435
• Protein ID: WP_001296726.1
• Coordinates: 687313..687579 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K09_RS03435 (687313)	687313..687579	+	267	WP_001296726.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
I6K09_RS03440 (687579)	687579..688274	+	696	WP_021523084.1	HipA N-terminal domain-containing protein	Toxin
I6K09_RS03445 (688474)	688474..689826	-	1353	WP_001551127.1	SIR2 family protein	-
I6K09_RS03450 (690041)	690041..691073	-	1033	Protein_684	ISNCY family transposase	-
I6K09_RS03455 (691440)	691440..692339	-	900	WP_001523294.1	LysR family transcriptional regulator	-
I6K09_RS03460 (692478)	692478..692786	+	309	WP_001221046.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	690041..690859	818

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-69)

Sequences

Toxin

Protein

• Length: 232 a.a.
• Molecular weight: 25773.79 Da
• Isoelectric Point: 9.9928

>T192290 WP_021523084.1 NZ_CP069957:687579-688274 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETIQAGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGVNASKGKKTAIDKI
YPRHFLATAKVLKFPEVQMHEILSDFARMIPAALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Nucleotide

• Length: 696 bp

>T192290 NZ_CP092284:1649149-1649403 [Marinobacter sp. M3C]
CTGGAACGATGCCGCAAATTCTTAGCCGCCAAAGCCCCGGAAGCCAGTAGGCGGGCAGGACAAACCATCGAACGGCACTT
CCTGTTTTTGGAAACAGCCACGGGTATTGGCCGGCCGTTCGCTGAAATGCCTGAATTGCGCGAATTAGTTATTGCCTTCG
GGAACTCCGGGTATGTGGCCCTGTACCACCATGAACCGGCCGACGATGCAGTATATGTTCTGGCCTTCCGGCACCAAAAA
GAAGCGGGCTTTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10047.39 Da
• Isoelectric Point: 4.9632

>AT192290 WP_001296726.1 NZ_CP069957:687313-687579 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Nucleotide

• Length: 267 bp

>AT192290 NZ_CP092284:1648850-1649122 [Marinobacter sp. M3C]
ATGGCAACATCTCTCAAAATCGACAACACACTAAAAAGCCGCGTTCATCACATCGCCAACCAACGCCGCCGCTCTCCGCA
CTGGATCATGCTGGAAGCCATACAGCAGTACGTTGAGCGCGAGGAAGCACGCGAGAGTTTCAAGCAGGAGGCCTTAGCGT
CTTGGTCAGCCTACAAGGAAACCGGCAGACACCTGACCGGCCAAGAAGCTCGCGCCTGGTTGAATACTTGGGGCAACGAT
GATGAGAAGGCGGCGCCAGAGTGCCACGAGTAA

Structures

Toxin

• AlphaFold DB: A0A1Q5ZNB7