Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 608323..608849 | Replicon | chromosome |
| Accession | NZ_CP069957 | ||
| Organism | Escherichia coli strain FDAARGOS_1279 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | I6K09_RS02990 | Protein ID | WP_000323025.1 |
| Coordinates | 608562..608849 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | I6K09_RS02985 | Protein ID | WP_000534858.1 |
| Coordinates | 608323..608562 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I6K09_RS02960 (603585) | 603585..604199 | + | 615 | WP_001265627.1 | hypothetical protein | - |
| I6K09_RS02965 (604202) | 604202..605224 | + | 1023 | WP_000915483.1 | DUF4868 domain-containing protein | - |
| I6K09_RS02970 (605729) | 605729..606751 | + | 1023 | Protein_584 | ISNCY family transposase | - |
| I6K09_RS25835 (606872) | 606872..607021 | + | 150 | WP_011443592.1 | protein YdfW | - |
| I6K09_RS02975 (607458) | 607458..607790 | - | 333 | WP_001301033.1 | FlxA-like family protein | - |
| I6K09_RS02980 (607993) | 607993..608298 | - | 306 | WP_001326990.1 | protein YdfV | - |
| I6K09_RS02985 (608323) | 608323..608562 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| I6K09_RS02990 (608562) | 608562..608849 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| I6K09_RS02995 (608921) | 608921..609076 | + | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| I6K09_RS03000 (609293) | 609293..609544 | + | 252 | WP_000980994.1 | protein Rem | - |
| I6K09_RS03005 (609611) | 609611..609889 | + | 279 | WP_012304870.1 | hypothetical protein | - |
| I6K09_RS03010 (609891) | 609891..610940 | + | 1050 | WP_001265199.1 | DUF968 domain-containing protein | - |
| I6K09_RS03015 (610954) | 610954..611706 | + | 753 | WP_001047135.1 | antitermination protein | - |
| I6K09_RS03020 (611984) | 611984..612073 | - | 90 | WP_120795389.1 | hypothetical protein | - |
| I6K09_RS03025 (612128) | 612128..612340 | - | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| I6K09_RS03030 (612641) | 612641..612856 | + | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| I6K09_RS03035 (613307) | 613307..613765 | + | 459 | WP_000526135.1 | IS200/IS605-like element IS200C family transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 591098..645879 | 54781 | |
| - | flank | IS/Tn | - | - | 613307..613765 | 458 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T192289 WP_000323025.1 NZ_CP069957:608562-608849 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T192289 NZ_CP092284:c1584562-1584290 [Marinobacter sp. M3C]
ATGTATTTTGAGTGGGATGACTCGAAGAACGCGGCCAATATCAGTAAACACGGAATAGACTTCAGAGATGCGATTGATAT
GTTCAATCACCCTATGCTGACAGCGATTGATGAGTGCTTTATGTACGGGGAAGAGCGATGGACAGCGATCGGGTTAATGC
GTGAAATGGTTGGCGTCGTCGTTTATACGGAGAGGCGTGAGAGCGTGGTGCGAATAATTTCTGCCCGAAAAGCGACCAGA
CGAGAGGTGAGGTTATATGAGCAAAACATCTAA
ATGTATTTTGAGTGGGATGACTCGAAGAACGCGGCCAATATCAGTAAACACGGAATAGACTTCAGAGATGCGATTGATAT
GTTCAATCACCCTATGCTGACAGCGATTGATGAGTGCTTTATGTACGGGGAAGAGCGATGGACAGCGATCGGGTTAATGC
GTGAAATGGTTGGCGTCGTCGTTTATACGGAGAGGCGTGAGAGCGTGGTGCGAATAATTTCTGCCCGAAAAGCGACCAGA
CGAGAGGTGAGGTTATATGAGCAAAACATCTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT192289 WP_000534858.1 NZ_CP069957:608323-608562 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT192289 NZ_CP092284:c1584306-1584052 [Marinobacter sp. M3C]
ATGAGCAAAACATCTAAGACAGACTGGAAGCGATTGACCGAAATGGAAGACGATGCAATCGACACCAGCGATATTTCCGA
GCTAGATGATAAATTTTTTCAGAACGCCGAACTTCTCATTCCAGCAAAACAGCCGGTGACTCTGCGAATCGATGAAGATG
TGCTGGTCTGGTTTAAGGCGCAGGGACGAGGGTACCAGACTCGCATTAATAAATTGTTGAGGCATTACATGGAGAGTCAG
GTTACGAAGCGCTGA
ATGAGCAAAACATCTAAGACAGACTGGAAGCGATTGACCGAAATGGAAGACGATGCAATCGACACCAGCGATATTTCCGA
GCTAGATGATAAATTTTTTCAGAACGCCGAACTTCTCATTCCAGCAAAACAGCCGGTGACTCTGCGAATCGATGAAGATG
TGCTGGTCTGGTTTAAGGCGCAGGGACGAGGGTACCAGACTCGCATTAATAAATTGTTGAGGCATTACATGGAGAGTCAG
GTTACGAAGCGCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|