Detailed information of TA system TA192279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 2214410..2215215
• Replicon: chromosome
• Accession: NZ_CP069954
• Organism: Staphylococcus epidermidis strain FDAARGOS_1364

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: I6K94_RS10540
• Protein ID: WP_002457885.1
• Coordinates: 2215033..2215215 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: -
• Locus tag: I6K94_RS10535
• Protein ID: WP_002476983.1
• Coordinates: 2214410..2215009 (+)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K94_RS10510	2209618..2211075	+	1458	WP_161388010.1	ABC transporter substrate-binding protein/permease	-
I6K94_RS10515	2211068..2211790	+	723	WP_204982899.1	ATP-binding cassette domain-containing protein	-
I6K94_RS10520	2212286..2212441	+	156	WP_059223918.1	hypothetical protein	-
I6K94_RS10525	2212655..2213785	+	1131	WP_001829814.1	tRNA epoxyqueuosine(34) reductase QueG	-
I6K94_RS10530	2213782..2214252	+	471	WP_059223911.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
I6K94_RS10535	2214410..2215009	+	600	WP_002476983.1	glucosamine-6-phosphate isomerase	Antitoxin
I6K94_RS10540	2215033..2215215	+	183	WP_002457885.1	hypothetical protein	Toxin
I6K94_RS10545	2215367..2215771	+	405	WP_002476981.1	hypothetical protein	-
I6K94_RS10550	2215955..2217340	+	1386	WP_193620713.1	class II fumarate hydratase	-
I6K94_RS10555	2217701..2218525	-	825	WP_193620714.1	RluA family pseudouridine synthase	-
I6K94_RS10560	2218684..2219817	+	1134	WP_001829819.1	GAF domain-containing sensor histidine kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	2212286..2212441	155

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (130-195)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 7080.67 Da
• Isoelectric Point: 4.3016

>T192279 WP_002457885.1 NZ_CP069954:2215033-2215215 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Nucleotide

• Length: 183 bp

>T192279 NZ_CP092283:c4521837-4521574 [Marinobacter sp. M4C]
GTGACATGGAAGTTGGTTTACACCAAACAGGCCCAAAAAGATGCAAAAAAGTTAGCTGCCAGCAGCCTCAAGCCAAAAGC
TCAGGGATTGTTGGCGCTGATTGCGGAAGATCCGTATCGGAGGCCGCCGCCGTTCGAAAAGCTCATTGGTGATCTTGCAG
GAGCATACTCTCGCCGCATCAATATCCAGCATCGTGTTGTTTACGAAGTGCTCGAAGATGAACGAGTGGTAAAAGTTCTC
CGGCTCTGGAGTCACTACGAATAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22679.60 Da
• Isoelectric Point: 4.9942

>AT192279 WP_002476983.1 NZ_CP069954:2214410-2215009 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Nucleotide

• Length: 600 bp

>AT192279 NZ_CP092283:c4522076-4521834 [Marinobacter sp. M4C]
ATGACCGGAATTACGGCAACTGAGGCGCGCAGCAACCTTTACAGGTTGATTGACGAAACGGCCGAGTCCCATCAACCAAT
CGTTATTATGGGTAAACGGAACAGGGCTGTTCTCGTTTCCGAGGAAGATTGGTCTGCGATTCAGGAAACGCTTTACCTGT
TATCTGTACCAGGTATGCGCGAGTCTATTCGAGAGGGAATGGAGACCCCTATGGATCAATGCGATGAGGAGCTGAACTGG
TGA