Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tsbAT/-
Location 2214410..2215215 Replicon chromosome
Accession NZ_CP069954
Organism Staphylococcus epidermidis strain FDAARGOS_1364

Toxin (Protein)


Gene name tsbT Uniprot ID -
Locus tag I6K94_RS10540 Protein ID WP_002457885.1
Coordinates 2215033..2215215 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name tsbA Uniprot ID -
Locus tag I6K94_RS10535 Protein ID WP_002476983.1
Coordinates 2214410..2215009 (+) Length 200 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K94_RS10510 2209618..2211075 + 1458 WP_161388010.1 ABC transporter substrate-binding protein/permease -
I6K94_RS10515 2211068..2211790 + 723 WP_204982899.1 ATP-binding cassette domain-containing protein -
I6K94_RS10520 2212286..2212441 + 156 WP_059223918.1 hypothetical protein -
I6K94_RS10525 2212655..2213785 + 1131 WP_001829814.1 tRNA epoxyqueuosine(34) reductase QueG -
I6K94_RS10530 2213782..2214252 + 471 WP_059223911.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
I6K94_RS10535 2214410..2215009 + 600 WP_002476983.1 glucosamine-6-phosphate isomerase Antitoxin
I6K94_RS10540 2215033..2215215 + 183 WP_002457885.1 hypothetical protein Toxin
I6K94_RS10545 2215367..2215771 + 405 WP_002476981.1 hypothetical protein -
I6K94_RS10550 2215955..2217340 + 1386 WP_193620713.1 class II fumarate hydratase -
I6K94_RS10555 2217701..2218525 - 825 WP_193620714.1 RluA family pseudouridine synthase -
I6K94_RS10560 2218684..2219817 + 1134 WP_001829819.1 GAF domain-containing sensor histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2212286..2212441 155


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Glucosamine-6-phosphate isomerase

(130-195)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7080.67 Da        Isoelectric Point: 4.3016

>T192279 WP_002457885.1 NZ_CP069954:2215033-2215215 [Staphylococcus epidermidis]
MANKKDSKLNYHEEENAMVTDLDDLKELGKEMEQISQENDEEKLNQPHDNEVRSDFKNSK

Download         Length: 183 bp

>T192279 NZ_CP092283:c4521837-4521574 [Marinobacter sp. M4C]
GTGACATGGAAGTTGGTTTACACCAAACAGGCCCAAAAAGATGCAAAAAAGTTAGCTGCCAGCAGCCTCAAGCCAAAAGC
TCAGGGATTGTTGGCGCTGATTGCGGAAGATCCGTATCGGAGGCCGCCGCCGTTCGAAAAGCTCATTGGTGATCTTGCAG
GAGCATACTCTCGCCGCATCAATATCCAGCATCGTGTTGTTTACGAAGTGCTCGAAGATGAACGAGTGGTAAAAGTTCTC
CGGCTCTGGAGTCACTACGAATAA

Antitoxin


Download         Length: 200 a.a.        Molecular weight: 22679.60 Da        Isoelectric Point: 4.9942

>AT192279 WP_002476983.1 NZ_CP069954:2214410-2215009 [Staphylococcus epidermidis]
MAMNFKVFDNSEKVAEYTADILRKQFNNNPTTIAGFHLSKEHAPVFDELKKNVENHAVDFSQINILDYDDNHSYYEALGV
PTGQIYSISYENDAIDFISDKIKTKENKGKLTMQVLTIDENGKLDISVRQGLMEAREIFLVITGANKRDMVEKLYRENGK
TSFEPSDLKAHRMVNVILDKEAAAGLPEDVKEYFTARFA

Download         Length: 600 bp

>AT192279 NZ_CP092283:c4522076-4521834 [Marinobacter sp. M4C]
ATGACCGGAATTACGGCAACTGAGGCGCGCAGCAACCTTTACAGGTTGATTGACGAAACGGCCGAGTCCCATCAACCAAT
CGTTATTATGGGTAAACGGAACAGGGCTGTTCTCGTTTCCGAGGAAGATTGGTCTGCGATTCAGGAAACGCTTTACCTGT
TATCTGTACCAGGTATGCGCGAGTCTATTCGAGAGGGAATGGAGACCCCTATGGATCAATGCGATGAGGAGCTGAACTGG
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References