Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 2048896..2049425 Replicon chromosome
Accession NZ_CP069954
Organism Staphylococcus epidermidis strain FDAARGOS_1364

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag I6K94_RS09580 Protein ID WP_001829891.1
Coordinates 2049063..2049425 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag I6K94_RS09575 Protein ID WP_001829931.1
Coordinates 2048896..2049066 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K94_RS09550 2044720..2045199 + 480 WP_002457111.1 PH domain-containing protein -
I6K94_RS09555 2045192..2046697 + 1506 WP_002457110.1 PH domain-containing protein -
I6K94_RS09560 2046684..2047193 + 510 WP_002457109.1 PH domain-containing protein -
I6K94_RS09565 2047241..2047594 + 354 WP_002457108.1 holo-ACP synthase -
I6K94_RS09570 2047661..2048809 + 1149 WP_002457107.1 alanine racemase -
I6K94_RS09575 2048896..2049066 + 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6K94_RS09580 2049063..2049425 + 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6K94_RS09585 2049770..2050771 + 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
I6K94_RS09590 2050871..2051197 + 327 WP_001829952.1 anti-sigma factor antagonist -
I6K94_RS09595 2051199..2051678 + 480 WP_001829903.1 anti-sigma B factor RsbW -
I6K94_RS09600 2051653..2052423 + 771 WP_002440602.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T192278 WP_001829891.1 NZ_CP069954:2049063-2049425 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T192278 NZ_CP092283:c3613436-3613173 [Marinobacter sp. M4C]
ATGGAAATTGAATTTGATAACGCTAAGAGCGAACGCAACATGGAGCTGAGAGGGCTTAGCTTCGAGCTGGCGGCAAAGTT
CGATTTCGATGGAGCGATTGAGGTAGAGCAGGAGGTAAATGGCGAACAGCGCTACTTTGCACTGGGCCATATAGGTTCCC
GCCTTTACGCTCTGGTCTATACGCTACGCACGAACATTGTTCGTGTAATCAGCCTGCGCAAAGCCAATAAACGTGAGGTG
AGACGCTATGAGCAATTCGATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT192278 WP_001829931.1 NZ_CP069954:2048896-2049066 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT192278 NZ_CP092283:c3613189-3612944 [Marinobacter sp. M4C]
ATGAGCAATTCGATTGACCCGGAAATGACAGATACAGACAACCCAGAGTGGTCTGATACTATGTTTGCCCAAGCCAAGCG
AGGCACGGCGGCTCGACGAGTAGGGCGGCCAAAGCTGAGGTCCCCCAAGCACTCCACCACGCTGCGAATTGATGAAGACG
TTATCGAGTTCTTCAAGAGCGGCGGTAGCGGCTGGCAGACCAGAATGAACGAAGCTCTGCGGCAATATGTATCGGAGCAT
AGTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References