Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2037712..2038221 Replicon chromosome
Accession NZ_CP069954
Organism Staphylococcus epidermidis strain FDAARGOS_1364

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag I6K94_RS09520 Protein ID WP_001829980.1
Coordinates 2038012..2038221 (+) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag I6K94_RS09515 Protein ID WP_001829893.1
Coordinates 2037712..2038005 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K94_RS09490 2032720..2033508 + 789 WP_001829971.1 hydroxyethylthiazole kinase -
I6K94_RS09495 2033514..2034152 + 639 WP_002505076.1 thiamine phosphate synthase -
I6K94_RS09500 2034241..2035113 + 873 WP_002458703.1 membrane protein insertase YidC -
I6K94_RS09505 2035219..2035872 - 654 WP_001829983.1 HD domain-containing protein -
I6K94_RS09510 2036054..2037538 - 1485 WP_002457116.1 cardiolipin synthase -
I6K94_RS09515 2037712..2038005 + 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6K94_RS09520 2038012..2038221 + 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
I6K94_RS09525 2038364..2038501 + 138 WP_001829949.1 hypothetical protein -
I6K94_RS09530 2038600..2039811 - 1212 WP_002486299.1 rod shape-determining protein RodA -
I6K94_RS09535 2040202..2041275 + 1074 WP_002468311.1 D-alanine--D-alanine ligase -
I6K94_RS09540 2041287..2042642 + 1356 WP_002457113.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T192277 WP_001829980.1 NZ_CP069954:2038012-2038221 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T192277 NZ_CP092283:c2885437-2884124 [Marinobacter sp. M4C]
GTGAGCACCGTTACGGAAGTTATCCTATGGGGGAAGAGTGTCGGTGCCCTGCTGTATGACACAGAAACCGGTCTGTCGAC
GTTCGAATACGATAAGGGTTGGTTGAAGCAGGACGTTTCAATTTCCCCGCTCCACCTACCTCCTCGGGCTGGGAGGTTCA
ATTTCCCCTCATTGCCACAGGAAACGTTCTTTGGACTGCCGGGCGTGTTTGCCGACACTTTGCCAGATGACTTTGGCAAT
GCCGTTATCAACGCTTGGCTGGCTCGCCAGGGAATCCCAAAAAGCTCATTCAGCCCGGTTGACCGCCTCCTATACACCGG
CAACCGTGGCATGGGTGCGCTGGAGTACAAGCCAGACGGCCGGAACACTCAGACTCAGGTATCAGGAGATATCAAGGTCG
ATACACTGGTCGAGTTGGCTCAGTCCGTGTTGGACCAAAGAGCTGGCCTGGATGTGGCCATATCAGAGGGTGATGAGAAC
AATGATGCGATGAGTGCCATTTTCCAGGTGGGCACATCGGCGGGTGGGGCTCGTCCCAAGGCCGTTATTGCCGTGAACCG
TGATCGTTCTCGGGTAGTTTCCGGCCAGACTCCCATACCCAAAGGATTCACTCACTACCTCATTAAATTCGATGGGGTCA
AAGAGCGATCATCCACCAGCGAGGTCTTTGGTGACCCGCAGGGGTATGGCCGGATGGAATATGCCTACTACCTGATGGCC
AAGGACGCAGGCATCAATATGGCACCGTCTGAACTGTTGATAGAAGGGGAGCGAGCCCATTTTATGACCCAGCGTTTCGA
CCGGGACGGTGACCGCAAGCGCCACTACCAGTCCCTATGCGCGATGGACCATGCGGACTTCCGGAAACCTGGGCAGTACA
GCTATGAAGAACTGATGACCATTGCCCGAACACTCGGGTTGCCACGGGTAGACGCAATCGAGATTTTCAGGCGTATGGTC
TTCAACGTCATTGCCCGGAACCAGGACGACCACACCAAGAACTTTGGCTTTCTGTTGGATCATTCAACGGCCGGTTGGCG
TTTGGCACCGGCGTTTGATATCGCCTACAGCTACAAACCCGGTTCATACTGGGTGGACACCCATCAGATGACCATCAACG
GTAAACGGGATAAGTTCACTCGCGGGGATATTCTCGCAGTCGCAACCCAAATTCCCCGTTTCGAGTCAAATGCCCGGGCC
ATTATTGACCAGGTAACTGAGGTGGTGAACCAATGGCAGGATTATGCTCGCCGAGCGGATGTCCATTCGGAGCTGTCACA
GGAGATTTACTCCAACCTCCGGTTGTCCTTGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT192277 WP_001829893.1 NZ_CP069954:2037712-2038005 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT192277 NZ_CP092283:c2885775-2885434 [Marinobacter sp. M4C]
ATGAGCCAAATTAAGCGCAGCATGTCAGACTTGGCCATCCTCGATGAGCTGGGTCGGCGCCTCAAGCAAGCCCGACTGGA
GCAAAACATCACCCAGCAGCAGATCGCAGAGGGCATGGGTGTCAGCCGAGCAACGTACATCCGGCTTGAGGATGGTAACG
GGAAACTTGAAGTCCTGGTTGCTGCCCTGCGTGTTCTCGGAAAGCTCCCGGCGTTGGATGCCTTCTTGCCAGATGAGCCT
TATTCACCGATTGCGGCATTAAAGAGTGCTGGCCATATTCGCCAGCGTGCACGCCCCGGTAATAAGCCCGTTGAACAGGA
CAAAGGAGACCTGGGCTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References