Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 1597357..1597866 Replicon chromosome
Accession NZ_CP069951
Organism Staphylococcus epidermidis strain FDAARGOS_1363

Toxin (Protein)


Gene name TsdT Uniprot ID Q5HMD5
Locus tag I6K93_RS07760 Protein ID WP_001829980.1
Coordinates 1597357..1597566 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID Q5HMD4
Locus tag I6K93_RS07765 Protein ID WP_001829893.1
Coordinates 1597573..1597866 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K93_RS07740 1592935..1594290 - 1356 WP_001832734.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -
I6K93_RS07745 1594302..1595375 - 1074 WP_001832735.1 D-alanine--D-alanine ligase -
I6K93_RS07750 1595766..1596977 + 1212 WP_001829910.1 rod shape-determining protein RodA -
I6K93_RS07755 1597077..1597214 - 138 WP_001829949.1 hypothetical protein -
I6K93_RS07760 1597357..1597566 - 210 WP_001829980.1 heavy-metal-associated domain-containing protein Toxin
I6K93_RS07765 1597573..1597866 - 294 WP_001829893.1 copper-sensing transcriptional repressor CsoR Antitoxin
I6K93_RS07770 1598040..1599524 + 1485 WP_001829964.1 cardiolipin synthase -
I6K93_RS07775 1599706..1600359 + 654 WP_001829983.1 HD domain-containing protein -
I6K93_RS07780 1600465..1601337 - 873 WP_001832740.1 membrane protein insertase YidC -
I6K93_RS07785 1601426..1602064 - 639 WP_002505076.1 thiamine phosphate synthase -
I6K93_RS07790 1602070..1602858 - 789 WP_001829971.1 hydroxyethylthiazole kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Metal-sensitive transcriptional repressor

(4-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7987.24 Da        Isoelectric Point: 7.0080

>T192276 WP_001829980.1 NZ_CP069951:c1597566-1597357 [Staphylococcus epidermidis]
MKLKKGLINVSGIKTTEQAKQLKDHLSKMIGINSVDIDYQMNEIRVEFDTPANLNNIEKEIYDYGFRIL

Download         Length: 210 bp

>T192276 NZ_CP092283:c2823307-2822912 [Marinobacter sp. M4C]
GTGATACGTATTTTCAAGTCAGTCACGATCCAAAAACTGTTCAAAGAACAGGATTTAGACGATCTCATCAACGACTTTCG
AAAGTACAAGGAAAGTGGTCTTTGCCCGGATTACTTTGGGCGGGATGTCGCCTATGATCACCCGCATACTCCATCGCTAA
TTCTGCAGGAAGATGTGCGTCACGTTCATTTATCAGAATTCGGCGCCTGGCCGGTTCGGCTAATGCAATTTAATCGCACG
AGTGATCGGCACCTGGTTTATTGTCAAGGTGCCATCCACAGGGAGTGTTACCTGCTCATCACACTTCTGAGCCCTGATGC
CCATGAGCAAGCCACCGTTAGCAACGTCATGCGCAAAATTGGAGAGCAAGCTGAAATTTTTCGAATGAAGTATTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11070.65 Da        Isoelectric Point: 5.5778

>AT192276 WP_001829893.1 NZ_CP069951:c1597866-1597573 [Staphylococcus epidermidis]
MADMESAHHSEQIKTNLKSRLNRIEGQVRAINRMIDDDVYCDDVLTQIRATRSALNSVATKLLDHHMKGCIMEKINDGAQ
EEAMDELLVTFQKLIKD

Download         Length: 294 bp

>AT192276 NZ_CP092283:c2823603-2823304 [Marinobacter sp. M4C]
ATGGCAACAAATGCTATCTTAGCGGAAAAGTCGGTCAGTATTTCTGCACTACGCAATAATCCGGCGCAGTATTTCCAAAA
CGAGCCTATTGCGGTTTTGAACCACAACAAGCCAGCAGGCTACATGATTGGTGCAGAGCTGTTTGAGAAGATGGTTCAGT
TGATTGGGGATCAGGAAGAATCGCGTACGTTTGTGGGACGTTTTCGTCCGCGAGGCTCTGAGCTTGCTGACCTCTGTAAA
AAGGGAGCTGACTTAATGCTGGAAACGACCCGAGAGGACATGGAGGGCTTCTCTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWU1

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EPA7

References