Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1586154..1586683 Replicon chromosome
Accession NZ_CP069951
Organism Staphylococcus epidermidis strain FDAARGOS_1363

Toxin (Protein)


Gene name mazF Uniprot ID Q5HME7
Locus tag I6K93_RS07700 Protein ID WP_001829891.1
Coordinates 1586154..1586516 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q5HME6
Locus tag I6K93_RS07705 Protein ID WP_001829931.1
Coordinates 1586513..1586683 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K93_RS07680 1583156..1583926 - 771 WP_002440602.1 RNA polymerase sigma factor SigB -
I6K93_RS07685 1583901..1584380 - 480 WP_001829903.1 anti-sigma B factor RsbW -
I6K93_RS07690 1584382..1584708 - 327 WP_001829952.1 anti-sigma factor antagonist -
I6K93_RS07695 1584808..1585809 - 1002 WP_001829902.1 PP2C family protein-serine/threonine phosphatase -
I6K93_RS07700 1586154..1586516 - 363 WP_001829891.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
I6K93_RS07705 1586513..1586683 - 171 WP_001829931.1 type II toxin-antitoxin system antitoxin MazE Antitoxin
I6K93_RS07710 1586770..1587918 - 1149 WP_001829972.1 alanine racemase -
I6K93_RS07715 1587984..1588337 - 354 WP_001829915.1 holo-ACP synthase -
I6K93_RS07720 1588385..1588894 - 510 WP_001829888.1 PH domain-containing protein -
I6K93_RS07725 1588881..1590386 - 1506 WP_001829976.1 PH domain-containing protein -
I6K93_RS07730 1590379..1590858 - 480 WP_001829909.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-112)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13497.65 Da        Isoelectric Point: 9.9522

>T192275 WP_001829891.1 NZ_CP069951:c1586516-1586154 [Staphylococcus epidermidis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTFLSESKMIEVDNALDISLGLNNFDHHKS

Download         Length: 363 bp

>T192275 NZ_CP092283:c1921878-1921600 [Marinobacter sp. M4C]
ATGATTCGAAGCTTCAAACACAAGGGCTTGGCCAAATTCTTCAAGTCCGGCAGCATCGCAGGGATTCAGGCCGCTCACGC
CAAGAGGCTTCGGCTTATTCTCGGTAGATTAAATGCAGCCTCAGATGCCAAAGATATGGACCTGCCAGGCCTTCGGTTGC
ACGAACTCTCCGGTAATCGCGCCGGAATCTGGTCAGTGATGGTCAGTGGCAACTGGCGAGTGACGTTCCGATTTGAGGAC
GGAGATGCCGAGATCGTAAATTATGAAGATTACCATTGA

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6289.92 Da        Isoelectric Point: 4.1920

>AT192275 WP_001829931.1 NZ_CP069951:c1586683-1586513 [Staphylococcus epidermidis]
MLSFNQNRNHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNESHLISNSKNE

Download         Length: 171 bp

>AT192275 NZ_CP092283:c1921589-1921302 [Marinobacter sp. M4C]
ATGTTGATGCATAACCCCCCCCACCCTGGTGAAGTACTGCGAGAGCTTTGTCTGGAGCCCCTGAACCTATCGGTCACGGC
GGCCGCAGAGGCATTGGGTGTTAGTCGTAAGACTTTGAGCGCCGTGCTGAACGGCAAGGCTGGTATTAGTCCCGAAATGG
CTATCCGGCTTTCTATAGCATTCGACACTTCGGCAGAGAGCTGGCTAAACCAGCAGTCCCAATATGAGCTCTGGCATGCT
GAACAACATCGCAAAGAGCTCAAGGTGAAGAAGCTTGTTGCGGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2G7HWR0

Antitoxin

Source ID Structure
AlphaFold DB A0A0N1EF65

References