Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4840144..4840763 Replicon chromosome
Accession NZ_CP069946
Organism Klebsiella pneumoniae strain FDAARGOS_1325

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag I6K55_RS23650 Protein ID WP_002892050.1
Coordinates 4840144..4840362 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag I6K55_RS23655 Protein ID WP_002892066.1
Coordinates 4840389..4840763 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K55_RS23615 4836187..4836450 + 264 WP_032432663.1 type B 50S ribosomal protein L31 -
I6K55_RS23620 4836450..4836590 + 141 WP_002892018.1 type B 50S ribosomal protein L36 -
I6K55_RS23625 4836587..4837285 - 699 WP_023287311.1 GNAT family N-acetyltransferase -
I6K55_RS23630 4837386..4838837 + 1452 WP_004183206.1 PLP-dependent aminotransferase family protein -
I6K55_RS23635 4838812..4839282 - 471 WP_020802585.1 YlaC family protein -
I6K55_RS23640 4839303..4839443 + 141 WP_004147370.1 hypothetical protein -
I6K55_RS23645 4839415..4839981 - 567 WP_002892030.1 maltose O-acetyltransferase -
I6K55_RS23650 4840144..4840362 - 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
I6K55_RS23655 4840389..4840763 - 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
I6K55_RS23660 4841249..4844395 - 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
I6K55_RS23665 4844418..4845611 - 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T192270 WP_002892050.1 NZ_CP069946:c4840362-4840144 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T192270 NZ_CP092283:c1047012-1046740 [Marinobacter sp. M4C]
GTGCTAACGCCAGTGCAATCGACCCAGTTCAAAAAAGACGTGAAGAAAGCCCGCAAGCGGGGCAAAGACTTGGACAAACT
AAAGATGTCGCTCAGTTTGCTGATTCGCCAGGCACCGTTACCCGAAGCTTATCAAGATCATCCTTTACGGGGGAACTGGA
AGGGCTATCGAGACGCGCATATTGAGCCGGACTGGTTGCTTTTGTACCGAGTGACCGACAAGGAATTGCAGTTAGCCCGA
ACCGGAACGCACGCGGATTTGTTTCAGGAGTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT192270 WP_002892066.1 NZ_CP069946:c4840763-4840389 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT192270 NZ_CP092283:c1047269-1047012 [Marinobacter sp. M4C]
ATGAATACCGATTCTGTAGTTCGTGCCCGCATCGACAGTGACACCAAAGCCCGCGCCACCGCCGCGCTGGACGCCATGGG
CCTGTCCGTTTCAGACGCCATACGCTTGCTCATGCTCAAGATTGCTGACGAACAGCGATTGCCGTTTGCGGTGCAAGTGC
CCAATGCCAAAACGGTCAAGGCCATGGAAGAGCTGGAAGCTGGCAAGGGCAAGCGTTTCAGTCACGAACAGGCGCTGTTT
GACGATCTGGGGTTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References