Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4061371..4061887 | Replicon | chromosome |
Accession | NZ_CP069946 | ||
Organism | Klebsiella pneumoniae strain FDAARGOS_1325 |
Toxin (Protein)
Gene name | relE | Uniprot ID | A0A2A2BGN7 |
Locus tag | I6K55_RS19985 | Protein ID | WP_009486548.1 |
Coordinates | 4061603..4061887 (+) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | I6K55_RS19980 | Protein ID | WP_002886901.1 |
Coordinates | 4061371..4061613 (+) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
I6K55_RS19965 | 4057399..4058139 | + | 741 | WP_009486551.1 | KDGP aldolase family protein | - |
I6K55_RS19970 | 4058206..4059360 | + | 1155 | WP_002886900.1 | lactonase family protein | - |
I6K55_RS19975 | 4059383..4061293 | + | 1911 | WP_009486549.1 | BglG family transcription antiterminator | - |
I6K55_RS19980 | 4061371..4061613 | + | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
I6K55_RS19985 | 4061603..4061887 | + | 285 | WP_009486548.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
I6K55_RS19990 | 4061891..4062355 | - | 465 | WP_002886903.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
I6K55_RS19995 | 4062663..4064801 | - | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
I6K55_RS20000 | 4065158..4065901 | - | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
I6K55_RS20005 | 4065904..4066077 | - | 174 | WP_032433782.1 | hypothetical protein | - |
I6K55_RS20010 | 4066162..4066470 | + | 309 | WP_012737232.1 | PTS sugar transporter subunit IIB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11125.95 Da Isoelectric Point: 10.4951
>T192267 WP_009486548.1 NZ_CP069946:4061603-4061887 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T192267 NZ_CP092283:c543535-543125 [Marinobacter sp. M4C]
GTGACTACGTACATGCTCGACACCTGTATCTGCTCATACATCATGCGAGAGCATCCGGCGTCAGTGTTACAGCGATTGAC
CTACGAGGTTGAGCAGGGCGACCGAATTGTCATTTCAGCCATTACGTATGCAGAAATGCGATACGGACAAATCGGCAAGA
AAGCTTCGGCCAAGCACAAGGTGTTGATTGATGAATTCGTAGAGCGAGTTGACGCCGTTCTGTCATGGGATCAGAGGGCG
GTAGACGCGACAGTCACTGCGATGAGCCAGCTTCGCAAAGCAGGCACTCCCATTGGCCCTAACGACACGGCCATCGCGGG
ACATGCAATCGCCACGGGTTGCACTCTAGTAACGAACAATGTTCGTGAATTTTCTCGTGTTCCTAGTCTCGTTTACGAAG
ACTGGGTTTAA
GTGACTACGTACATGCTCGACACCTGTATCTGCTCATACATCATGCGAGAGCATCCGGCGTCAGTGTTACAGCGATTGAC
CTACGAGGTTGAGCAGGGCGACCGAATTGTCATTTCAGCCATTACGTATGCAGAAATGCGATACGGACAAATCGGCAAGA
AAGCTTCGGCCAAGCACAAGGTGTTGATTGATGAATTCGTAGAGCGAGTTGACGCCGTTCTGTCATGGGATCAGAGGGCG
GTAGACGCGACAGTCACTGCGATGAGCCAGCTTCGCAAAGCAGGCACTCCCATTGGCCCTAACGACACGGCCATCGCGGG
ACATGCAATCGCCACGGGTTGCACTCTAGTAACGAACAATGTTCGTGAATTTTCTCGTGTTCCTAGTCTCGTTTACGAAG
ACTGGGTTTAA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT192267 WP_002886901.1 NZ_CP069946:4061371-4061613 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT192267 NZ_CP092283:c543762-543532 [Marinobacter sp. M4C]
ATGCGGACTGTTTCTATTTTCAAAAACGGCAAAAATCAGGCCGTGCGATTACCTGCTGACATGGCCTATACCGGCGTTGG
AGAGCTTGAAATTTCGCGAGACGGGGACGTAATCACTCTTCGCCCTGTCAGGGCATCTTGGGCTTCTTTTGCCGATCTCC
CAAAAGCGGACGCCGATTTCCTTAATGAGCGCCCCGTGGTCGCGAGTGATGAAAGCAGGTTTAATCTGTGA
ATGCGGACTGTTTCTATTTTCAAAAACGGCAAAAATCAGGCCGTGCGATTACCTGCTGACATGGCCTATACCGGCGTTGG
AGAGCTTGAAATTTCGCGAGACGGGGACGTAATCACTCTTCGCCCTGTCAGGGCATCTTGGGCTTCTTTTGCCGATCTCC
CAAAAGCGGACGCCGATTTCCTTAATGAGCGCCCCGTGGTCGCGAGTGATGAAAGCAGGTTTAATCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2A2BGN7 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |