Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4061371..4061887 Replicon chromosome
Accession NZ_CP069946
Organism Klebsiella pneumoniae strain FDAARGOS_1325

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag I6K55_RS19985 Protein ID WP_009486548.1
Coordinates 4061603..4061887 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag I6K55_RS19980 Protein ID WP_002886901.1
Coordinates 4061371..4061613 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K55_RS19965 4057399..4058139 + 741 WP_009486551.1 KDGP aldolase family protein -
I6K55_RS19970 4058206..4059360 + 1155 WP_002886900.1 lactonase family protein -
I6K55_RS19975 4059383..4061293 + 1911 WP_009486549.1 BglG family transcription antiterminator -
I6K55_RS19980 4061371..4061613 + 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I6K55_RS19985 4061603..4061887 + 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I6K55_RS19990 4061891..4062355 - 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I6K55_RS19995 4062663..4064801 - 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
I6K55_RS20000 4065158..4065901 - 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
I6K55_RS20005 4065904..4066077 - 174 WP_032433782.1 hypothetical protein -
I6K55_RS20010 4066162..4066470 + 309 WP_012737232.1 PTS sugar transporter subunit IIB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T192267 WP_009486548.1 NZ_CP069946:4061603-4061887 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T192267 NZ_CP092283:c543535-543125 [Marinobacter sp. M4C]
GTGACTACGTACATGCTCGACACCTGTATCTGCTCATACATCATGCGAGAGCATCCGGCGTCAGTGTTACAGCGATTGAC
CTACGAGGTTGAGCAGGGCGACCGAATTGTCATTTCAGCCATTACGTATGCAGAAATGCGATACGGACAAATCGGCAAGA
AAGCTTCGGCCAAGCACAAGGTGTTGATTGATGAATTCGTAGAGCGAGTTGACGCCGTTCTGTCATGGGATCAGAGGGCG
GTAGACGCGACAGTCACTGCGATGAGCCAGCTTCGCAAAGCAGGCACTCCCATTGGCCCTAACGACACGGCCATCGCGGG
ACATGCAATCGCCACGGGTTGCACTCTAGTAACGAACAATGTTCGTGAATTTTCTCGTGTTCCTAGTCTCGTTTACGAAG
ACTGGGTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT192267 WP_002886901.1 NZ_CP069946:4061371-4061613 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT192267 NZ_CP092283:c543762-543532 [Marinobacter sp. M4C]
ATGCGGACTGTTTCTATTTTCAAAAACGGCAAAAATCAGGCCGTGCGATTACCTGCTGACATGGCCTATACCGGCGTTGG
AGAGCTTGAAATTTCGCGAGACGGGGACGTAATCACTCTTCGCCCTGTCAGGGCATCTTGGGCTTCTTTTGCCGATCTCC
CAAAAGCGGACGCCGATTTCCTTAATGAGCGCCCCGTGGTCGCGAGTGATGAAAGCAGGTTTAATCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References