Detailed information of TA system TA192266

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 3900456..3902137
• Replicon: chromosome
• Accession: NZ_CP069946
• Organism: Klebsiella pneumoniae strain FDAARGOS_1325

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: A6TH06
• Locus tag: I6K55_RS19180
• Protein ID: WP_015959269.1
• Coordinates: 3901262..3902137 (+)
• Length: 292 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: A6TH05
• Locus tag: I6K55_RS19175
• Protein ID: WP_004177809.1
• Coordinates: 3900456..3901214 (+)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K55_RS19160	3895958..3896644	-	687	WP_004151733.1	sel1 repeat family protein	-
I6K55_RS19165	3897222..3899369	-	2148	WP_012737173.1	formate dehydrogenase H subunit alpha, selenocysteine-containing	-
I6K55_RS19170	3899642..3900370	+	729	WP_032413197.1	response regulator transcription factor	-
I6K55_RS19175	3900456..3901214	+	759	WP_004177809.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
I6K55_RS19180	3901262..3902137	+	876	WP_015959269.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
I6K55_RS19185	3902262..3903269	-	1008	WP_015959270.1	carbohydrate kinase family protein	-
I6K55_RS19190	3903344..3904285	-	942	WP_002885156.1	ABC transporter substrate-binding protein	-
I6K55_RS19195	3904316..3905314	-	999	WP_002885172.1	ribose ABC transporter permease	-
I6K55_RS19200	3905311..3906831	-	1521	WP_002885173.1	sugar ABC transporter ATP-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (7-264)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 292 a.a.
• Molecular weight: 32990.17 Da
• Isoelectric Point: 5.4637

>T192266 WP_015959269.1 NZ_CP069946:3901262-3902137 [Klebsiella pneumoniae]
MQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQAGMSAVLQANRSDE
MRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQHPRDFYDVKLLLDAQ
ELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKSCITQQDVDFLLSFK
RGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 876 bp

>T192266 NZ_CP092264:c2185022-2184759 [Levilactobacillus brevis]
ATGAATAAATTATTTACGGAAAATGCTTGGCAAGACTATCTTTGGCTGTTAAAGAACGATAGGCGGGCTTTAAAACGAGT
CAATCTGTTACTGCAGGATATCTCACGTACACCATTTAGTGGAATAGGTAAGCCGGAGTCGTTGCATGGCGATTTCACAG
GGTATTGGTCTCGTCGAGTTAATGAAAAAGATCGTTTGGTTTACGCTGCAGATGAGAAAACGATTACGATACTTGCCTGC
CGAACGCATTACGGTGATAAGTGA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28548.92 Da
• Isoelectric Point: 10.0870

>AT192266 WP_004177809.1 NZ_CP069946:3900456-3901214 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT192266 NZ_CP092264:c2185284-2185015 [Levilactobacillus brevis]
ATGGAAGCAACAACGTATACGGATTTTCGTAAGAATTTAAAGAAATATATGGACAAGGCAACTGGGGATTTTGAGCCAAT
CACGATTACGCGTAAAGATCACCAGAATGCAGTTCTTATCTCAGAAGAAGAGTATAACAACATGCTTGAAAATCGCTATA
TTTTAGATAATCCGACTAACCGTGAGTGGCTTCAAGCATCACTGAAACAGGCGAAGGACGGCCAGGTAGCCGCACACCAC
TTAGTGACCCCGAGTGCTGATGATGAATAA

Structures

Toxin

• AlphaFold DB: A6TH06

Antitoxin

• AlphaFold DB: A6TH05