Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2652329..2652986 Replicon chromosome
Accession NZ_CP069946
Organism Klebsiella pneumoniae strain FDAARGOS_1325

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I6K55_RS13045 Protein ID WP_002916310.1
Coordinates 2652329..2652739 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I6K55_RS13050 Protein ID WP_002916312.1
Coordinates 2652720..2652986 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K55_RS13025 2648329..2650062 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
I6K55_RS13030 2650068..2650781 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K55_RS13035 2650804..2651700 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I6K55_RS13040 2651801..2652322 + 522 WP_004144730.1 flavodoxin FldB -
I6K55_RS13045 2652329..2652739 - 411 WP_002916310.1 protein YgfX Toxin
I6K55_RS13050 2652720..2652986 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I6K55_RS13055 2653232..2654215 + 984 WP_002916313.1 tRNA-modifying protein YgfZ -
I6K55_RS13060 2654366..2655025 - 660 WP_002916317.1 hemolysin III family protein -
I6K55_RS13065 2655189..2655500 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I6K55_RS13070 2655550..2656278 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I6K55_RS13075 2656397..2657830 + 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T192262 WP_002916310.1 NZ_CP069946:c2652739-2652329 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T192262 NZ_CP092258:4548931-4549242 [Salmonella enterica subsp. enterica serovar Indiana]
GTGCATGTTATCAGCCGAAAACCGTTCAATGAAGCGATGCTCATGTATCCAAACCATGAGCTTGCCCTCACTGAGTTGCT
GAATGTTCTGGAGAAAAAAACATTCACTCAGCCTGAAGAGATGAAGCGGTATATTCCTTCACTGGATAATTTTAAGTACA
GAGATAAATGGTGGGTGATTGATGTTTCTGGTAACAGCCTGAGACTCATTTCCTACATAGATTTCAGGTTACATAAGATA
TTTGTGAAACATATCGTTTCCCATGCCGAATATGACAAACTGACCGCATATTATCGGGGTAATGAAGAATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT192262 WP_002916312.1 NZ_CP069946:c2652986-2652720 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192262 NZ_CP092258:4549239-4549685 [Salmonella enterica subsp. enterica serovar Indiana]
ATGAGAACTCATCGTCAGATGGATGCAACCAGCGCAAAAAAGATCGTTGATACCTTCAGCGATGCGGTAAAAAGCGTCCC
ACTGATGGGGGAAGACCGAAATGACAATGAGTATCGCAGGGCACTAGCGCTAGTGGAGTTTCTGGTCGACCACGACGATC
TTGAAAACCCACTATTTGAATTGCTCTGTGCCCGAATCAGTGAATACGAAAAACATGCGCCGGAATTCAAAGCACTCAAC
CAACACCTGGAGAAAACGCCCCCTGGCGTTTCAGTATTGCGAACGCTCATGGATCAATACGGTCTCAAAGCAGCAGATCT
TGCCAACGAACTTGGTTCTAAATCGAACGTCAGCAACATCTTAAATGGCCGCAGAGCACTAACGGTTAATCATATTAAAG
CGCTTACACAACGCTTTAAACTACCAGCGGATGCCTTCATCGAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References