Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1027326..1028124 Replicon chromosome
Accession NZ_CP069945
Organism Escherichia coli strain FDAARGOS_1373

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VRA6
Locus tag I6L03_RS04760 Protein ID WP_000854730.1
Coordinates 1027326..1027703 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P0SQV8
Locus tag I6L03_RS04765 Protein ID WP_001285481.1
Coordinates 1027750..1028124 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6L03_RS23025 (1023124) 1023124..1023318 - 195 WP_001313570.1 DUF957 domain-containing protein -
I6L03_RS04735 (1023360) 1023360..1023651 + 292 Protein_915 transposase -
I6L03_RS04740 (1023648) 1023648..1023998 + 351 WP_000624707.1 IS66 family insertion sequence element accessory protein TnpB -
I6L03_RS04745 (1024029) 1024029..1025622 + 1594 Protein_917 IS66 family transposase -
I6L03_RS04750 (1025770) 1025770..1026758 + 989 Protein_918 IS630 family transposase -
I6L03_RS04755 (1026837) 1026837..1027329 - 493 Protein_919 DUF5983 family protein -
I6L03_RS04760 (1027326) 1027326..1027703 - 378 WP_000854730.1 TA system toxin CbtA family protein Toxin
I6L03_RS04765 (1027750) 1027750..1028124 - 375 WP_001285481.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I6L03_RS04770 (1028174) 1028174..1028818 - 645 WP_000086759.1 hypothetical protein -
I6L03_RS04775 (1028837) 1028837..1029058 - 222 WP_000692315.1 DUF987 domain-containing protein -
I6L03_RS04780 (1029121) 1029121..1029597 - 477 WP_001313574.1 RadC family protein -
I6L03_RS04785 (1029613) 1029613..1030086 - 474 WP_001313575.1 antirestriction protein -
I6L03_RS04790 (1030180) 1030180..1030425 - 246 WP_001164966.1 hypothetical protein -
I6L03_RS04795 (1030425) 1030425..1031246 - 822 WP_001234359.1 DUF932 domain-containing protein -
I6L03_RS04800 (1031346) 1031346..1031579 - 234 WP_001213776.1 DUF905 family protein -
I6L03_RS04805 (1031697) 1031697..1032149 - 453 WP_000682723.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14212.21 Da        Isoelectric Point: 7.2923

>T192227 WP_000854730.1 NZ_CP069945:c1027703-1027326 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRSNYRMVNDIIRGEHSEAKR

Download         Length: 378 bp

>T192227 NZ_CP092203:c3541739-3541398 [Leptospira weilii]
ATGATTCGTGGTGAAATTTGGTGGGTAGACTTGGGAATTCCCTTTGGAAGTGAGCCAGGATTCAAACGTCCGGTTTTGAT
AATTCAAGATGACTCTTTTAATCAAAGTAATATTAATACAATAGTTTCGATTGCAATTACATCGAATTTAAATCTATCCG
AAGCACCAGGTAACGTTTTAATTAGTAAGAAAGATTCGAATTTATCAAAGGATTCAGTCGTAAATGTCTCTCAAATTGTG
ACTTTAGATAAAAAAAGATTTCTTAATAAAGTAGGAAAACTTAAATCCAATAAACTAAATGAAGTTGAAGCGGGGCTAAA
GTTAGTTACAGACTTAGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13817.53 Da        Isoelectric Point: 4.7511

>AT192227 WP_001285481.1 NZ_CP069945:c1028124-1027750 [Escherichia coli]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTIG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT192227 NZ_CP092203:c3541974-3541726 [Leptospira weilii]
ATGAAAACGGCAATCTCAATTCCTGATGAGCTATTTAAGACCGCAGAAAAAACAGCTAAAAAGCTTGGTATTCCTCGTAG
TCAGTTATTTGCAAAAGCATTAGAGGAATTTATTCAATCTCATAGTAAAGAATCCGTAACTGAGAAATTAAATAAAGTCT
ACAATAGTAAATCTAGCGAAACTAAAAATAACATCACTGACTTATCCGTAGAATCACTTCGCAAAAGTTTAAAAAATGAT
TCGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V671

Antitoxin

Source ID Structure
AlphaFold DB A0A0P0SQV8

References