Detailed information of TA system TA192219

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX(toxin)
• Location: 5632535..5633354
• Replicon: chromosome
• Accession: NZ_CP069943
• Organism: Klebsiella oxytoca strain FDAARGOS_1332

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: I6K62_RS26205
• Protein ID: WP_004110819.1
• Coordinates: 5633097..5633354 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: I6K62_RS26200
• Protein ID: WP_004099227.1
• Coordinates: 5632535..5633086 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I6K62_RS26185	5627864..5629261	+	1398	WP_077257937.1	MFS transporter	-
I6K62_RS26190	5629385..5630725	+	1341	WP_024273771.1	carbohydrate porin	-
I6K62_RS26195	5630889..5632517	-	1629	WP_049593479.1	SAM-dependent methyltransferase	-
I6K62_RS26200	5632535..5633086	-	552	WP_004099227.1	N-acetyltransferase	Antitoxin
I6K62_RS26205	5633097..5633354	-	258	WP_004110819.1	YjhX family toxin	Toxin
I6K62_RS26210	5633937..5635121	+	1185	WP_049593480.1	mannonate dehydratase	-
I6K62_RS26215	5635196..5636671	+	1476	WP_004110817.1	fructuronate reductase	-
I6K62_RS26220	5636807..5637583	+	777	WP_017146569.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (17-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T192219 WP_004110819.1 NZ_CP069943:c5633354-5633097 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T192219 NZ_CP092184:4944816-4945166 [Serratia marcescens]
ATGGTGAAGCGCCCCGTTTTTCAGCGCGGAGATCTTATCCGGGTCAGCCTGAATCCCGTGGTTGGCCGTGAGCAGCAAGG
CGACTTTCGTCCGGCACTGGTGCTCTCTCCCCGCGAGTTTAATGCGTTGGGCATGGTGCTGGTCGCCCCTATTTCGCAAG
GGGCTAATTTTGCCCGTACAGCGGGTTTCACCGTCAGCCTGAGCGGGAGCGGCACCGCAACGCAGGGCGTCATCTTGATC
AACCAGGTTCGCATGATGGATCTGGCCGGGCGCAGCGCGCAATTCATTGAACGTGCCCCTGGCGAAGTCATCGCCGACGC
GCTGGCGCGGCTTCAGGCAATCATCGACTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20246.21 Da
• Isoelectric Point: 6.7178

>AT192219 WP_004099227.1 NZ_CP069943:c5633086-5632535 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPRLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGMGVGGLLIQSGIEHLKAMGSLAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGITGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT192219 NZ_CP092184:4944574-4944822 [Serratia marcescens]
ATGAAAGTCTTTATCAAAAAATGGGGCAACAGCGCGGGAATGCTGGTGCCCTCAGCGCTAATGAACGAGCTGGAACTACA
GGTAGGTCAGGAAATGGACATGCAGGTCATCGATGGAGCGTTGGTCATTAAACCGGTTAAGAAACGCTATTCACTGCAGC
AATTGCTCGATGGCTGCGACGGTGAAGCGCCGGCCGCCGCAGACGACAACTGGGAACACATGCCGCCGGCGGGGAAAGAA
GTATGGTGA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2