Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1933814..1934471 Replicon chromosome
Accession NZ_CP069943
Organism Klebsiella oxytoca strain FDAARGOS_1332

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag I6K62_RS09155 Protein ID WP_004105559.1
Coordinates 1934061..1934471 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag I6K62_RS09150 Protein ID WP_004105561.1
Coordinates 1933814..1934080 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I6K62_RS09125 1928994..1930427 - 1434 WP_049128113.1 6-phospho-beta-glucosidase -
I6K62_RS09130 1930548..1931276 - 729 WP_075551476.1 MurR/RpiR family transcriptional regulator -
I6K62_RS09135 1931327..1931638 + 312 WP_004105571.1 N(4)-acetylcytidine aminohydrolase -
I6K62_RS09140 1931800..1932459 + 660 WP_004105569.1 hemolysin III family protein -
I6K62_RS09145 1932587..1933570 - 984 WP_004115279.1 tRNA-modifying protein YgfZ -
I6K62_RS09150 1933814..1934080 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
I6K62_RS09155 1934061..1934471 + 411 WP_004105559.1 protein YgfX Toxin
I6K62_RS09160 1934480..1935001 - 522 WP_004105557.1 flavodoxin FldB -
I6K62_RS09165 1935123..1936019 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
I6K62_RS09170 1936042..1936755 + 714 WP_024274699.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I6K62_RS09175 1936761..1938494 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T192209 WP_004105559.1 NZ_CP069943:1934061-1934471 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

>T192209 NZ_CP092184:1659678-1659986 [Serratia marcescens]
ATGCAATTTACCGTATATGACAATACGTATCCGGCATCAGCCTATCCCTACTTACTGGACGTTCAAAGCGATCTTATTGA
TGTCCTCTCGACCCGGTTAATGATCCCTCTTTATGCTTTGGATAACGTCAGGGTTAAAATTTCTGCACGTTTATGCCCGG
AGATTGAGGTCAACGGCGAAAAGTTTCTTGTTATGACGCATGAGATGGCTGCCGTACGTATTTCGCAGATTGGGAAGGCC
GTTGGTAATGTCAATGAGCACAGGAATCAAATTAAAGCCGCTATCGATTTTCTGATTGATGGCTTTTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT192209 WP_004105561.1 NZ_CP069943:1933814-1934080 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT192209 NZ_CP092184:1659439-1659675 [Serratia marcescens]
ATGGCAAATAGCAATGTGACGAAAAAGACAGTCAACGTAACCATCGATCGCGATCTTTTCCAGCGCGCAAAATCCCTGGG
CGTCAATGTGTCATCCGTATTGACAGACGCATTGAGCGTCCGCGTCAGGGATATTGAGATTCAACAGTGGCGCGAGCAAA
ATCGCGCGGCGTTAGAAGAACTTAATCGTATCACTGAAGAAAATGGTTTGTTGTCTGATGAATATCGGACATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References